Journal Article10.1097/00005537-199606000-00007
Growth Rate Characteristics of Acoustic Neuromas Associated With Neurofibromatosis Type 2
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TL;DR: Magnetic resonance images and audiologic data on 22 patients with NF2 who underwent multiple studies at the National Institutes of Health between 1983 and 1993 were reviewed to determine the growth characteristics of ANs in these patients.
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Abstract: Neurofibromatosis type 2 (NF2) is a dominantly inherited disorder characterized by the occurrence of bilateral acoustic neuromas (ANs) and other central nervous system tumors. Magnetic resonance images and audiologic data on 22 patients with NF2 who underwent multiple studies at the National Institutes of Health between 1983 and 1993 were reviewed to determine the growth characteristics of ANs in these patients. The average growth rate of ANs in NF2 patients was 0.30 cm 3 per year and was significantly higher in older patients (0.75 cm 3 per year) than in younger ones (0.12 cm 3 per year). Larger ANs were more commonly found in patients with concomitant spinal tumors or meningiomas. NF2 patients with spinal tumors but not meningiomas demonstrated faster growth rates than patients without additional tumor burden. The data from this study suggest that older patients or patients with associated spinal tumors have faster growing ANs and therefore should be followed closely and treated aggressively.
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Citations
Long-term natural history of neurofibromatosis Type 2-associated intracranial tumors.
Michael S Dirks,John A. Butman,H. Jeffrey Kim,Tianxia Wu,Keaton Morgan,Anne P. Tran,Russell R. Lonser,Ashok R. Asthagiri +7 more
TL;DR: Neurofibromatosis Type 2-associated intracranial tumors most frequently demonstrated a saltatory growth pattern, and resection may be best reserved for symptom-producing tumors.
Vestibular schwannoma growth in patients with neurofibromatosis Type 2: a longitudinal study
Victor-Felix Mautner,Michael E. Baser,Sarang D Thakkar,Urs M Feigen,Jan M. Friedman,Lan Kluwe +5 more
TL;DR: There is considerable variability in growth rates of VSs in patients with NF2, but they tend to be higher in patients who are younger at onset of signs or symptoms, while the number of non-VS cerebral or spinal tumors or different types of constitutional NF2 mutations is unknown.
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Predictors of vestibular schwannoma growth in patients with neurofibromatosis Type 2.
TL;DR: The growth rates of vestibular schwannomas in patients with NF2 are highly variable, but tend to decrease with increasing patient age, and clinical treatment of multiple patients in families withNF2 cannot be based on the expectations of similar VS growth rates, even when other clinical aspects of disease severity are similar.
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Concordance of bilateral vestibular schwannoma growth and hearing changes in neurofibromatosis 2: neurofibromatosis 2 natural history consortium.
TL;DR: Clinically, tumor change or hearing deterioration on one VS cannot be used to predict changes in the other VS, which suggests that, although NF2 is a Mendelian disease, the germline genotype-phenotype relationship may resemble that of complex disorders.
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Stereotactic radiosurgery for neurofibromatosis 2-associated vestibular schwannomas: toward dose optimization for tumor control and functional outcomes.
Grant W. Mallory,Bruce E. Pollock,Robert L. Foote,Matthew L. Carlson,Colin L. W. Driscoll,Michael J. Link +5 more
TL;DR: Higher marginal doses than commonly prescribed for sporadic VS were associated with improved tumor control in patients with NF2, and further consideration should be given to optimum dosing to achieve long-term control while maximizing functional outcomes.
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References
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TL;DR: A candidate gene for the NF2 tumor suppressor that has suffered nonoverlapping deletions in DNA from two independent NF2 families and alterations in meningiomas from two unrelated NF2 patients is identified.
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TL;DR: Patients with acoustic tumors initially were treated conservatively and have been followed up for an average of 26 ± 2 months, and the tumor size was determined by the mean maximum anteroposterior and mediolateral diameters, using computed tomographic or magnetic resonance imaging scans.
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Volume growth rate of acoustic neurinomas
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TL;DR: Of 79 acoustic neurinomas seen between June 1980 and June 1984, at least two CT scans were available for each of 23 tumours, with no single clinical, radiological or histological feature correlated with any type of growth rate.
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The Growth Rate of Acoustic Neuromas
TL;DR: Growth rate of acoustic neuromas (AN) was studied and the growth rate of unilateral AN was lower than that of bilateral AN associated with neurofibromatosis2 (NF2) and that of non-operative tumor volume doubling time (VDT).
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