Growth pattern, an important pathologic prognostic parameter for clear cell renal cell carcinoma.

TL;DR: Growth pattern can be considered a new prognostic parameter for ccRCC and was useful predictors of disease-free survival (DFS) and cancer-specific survival (CSS), although only 30 cases showed the infiltrative pattern.

Abstract: Objectives: To assess the validity of growth pattern as a unique prognostic parameter for clear cell renal cell carcinoma (ccRCC). Methods: In total, 561 patients with pathologic tumor stage 1 (pT1), pT2, and pT3a ccRCC without preoperative metastasis were evaluated. Clinicopathologic parameters, including pathologic tumor stage, Fuhrman grade, tumor necrosis, lymphovascular invasion, and growth pattern, were analyzed to predict disease-free survival (DFS) and cancer-specific survival (CSS). Results: Growth patterns were defined as follows: expansive included tumors with well-circumscribed margins without normal renal tissue in the tumor, and infiltrative involved tumors with ill-circumscribed margins or normal renal tissue in the tumors. In multivariate analysis, Fuhrman grade, tumor necrosis, and growth pattern were useful predictors of DFS, whereas Fuhrman grade and growth pattern were useful predictors of CSS, although only 30 cases showed the infiltrative pattern. Conclusions: Growth pattern can be considered a new prognostic parameter for ccRCC.