Journal Article10.1097/00006842-199105000-00005
Group size, cage shelf level, and emotionality in non-obese diabetic mice: impact on onset and incidence of IDDM.
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TL;DR: Emotionality may be a mediating factor in animals genetically predisposed to develop IDDM and cage shelf level should be incorporated into the design of studies in which IDDM is the outcome.
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Abstract: We hypothesized that differential housing, shown to influence emotionality and health in infectious and neoplastic disease, would influence onset/incidence of diabetes in an autoimmune animal model of insulin-dependent diabetes mellitus (IDDM). Non-obese diabetic mice were assigned to same-sex groups of one, five, or eight animals/cage, counterbalanced across shelf level by sex and group. During weekly urine glucose testing, presence of behaviors indicating emotional arousal was recorded. Sex, group, and shelf level affected emotionality: males, animals housed alone, and those on the top of the rack exhibited higher emotionality. Emotionality and shelf level predicted IDDM in females only. Delayed onset of IDDM was associated with high emotionality and with being housed on the top of the rack. Group size had no significant effect on IDDM. Emotionality may be a mediating factor in animals genetically predisposed to develop IDDM. This variable and cage shelf level should be incorporated into the design of studies in which IDDM is the outcome.
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References
Type I diabetes mellitus. A chronic autoimmune disease.
TL;DR: Evidence has suggested that progressive loss of first-phase insulin secretion precedes diabetes, and immunologic findings have suggested that selection of selected assays for islet-cell antibodies has been defined.
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•Journal Article
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TL;DR: Results suggest a defect in suppressor cell activation rather than an absence of this immunoregulatory cell population in nonobese diabetic mice.
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Cage design reduces emotionality in mice
TL;DR: Results suggest that a more natural housing environment would lead to healthier animals and that mice were less emotional when reared in the more complex cages.
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