Graphical analysis of PET data applied to reversible and irreversible tracers.

TL;DR: A potent and selective F-labeled DAT ligand that provides cocaine-like pharmacokinetic properties is discovered and a series of cocaine analogues with improved affinity and selectivity profiles relative to ( )-cocaine are designed and synthesized.

TL;DR: There have been considerable advances in this area in the last five years, including the development of novel radioligands as well as the use of more established radiolIGands to evaluate changes in DAT-density in various disease states, and to estimate the degree of occupancy of the DAT associated with drug effects.

TL;DR: This study validates the use of image-derived input functions (IDIFs) from a long axial field of view PET/CT scanner for two tracers, [18F]FDG and [18F]DPA-714, with varying reconstruction settings and IDIF locations, demonstrating high accuracy and precision for [18F]FDG but not [18F]DPA-714 without calibration.

TL;DR: The purpose of the present study was to define the optimal reference tissue model based on a comparison with a validated plasma input model and using clinical studies and Monte Carlo simulations, which indicated that low-specific binding results in decreased accuracy and reproducibility.

TL;DR: General equations are derived that can be used to analyze tissue uptake data when the blood–plasma concentration of the test substance cannot be easily measured and for situations when trapping of theTest substance is incomplete and for a combination of these two conditions.

TL;DR: In this paper, the authors proposed a graphical method for determining the distribution volume ratio (DVR), which is a linear function of receptor availability, which does not require blood sampling and is widely used as a model parameter in imaging studies.

TL;DR: It can be shown that, for many systems, linearity is effectively reached some time before this, and this method provides an easy, rapid method for comparison of the reproducibility of repeated measures in a single subject, for longitudinal or drug intervention protocols, or for comparing experimental results between subjects.

TL;DR: An infusion protocol consisting of bolus plus continuous infusion of CF was designed and applied and has the potential to shorten scan time and simplify the acquisition and processing of scan and blood data.