Graphical analysis of PET data applied to reversible and irreversible tracers.
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TL;DR: In this paper, the authors apply graphical analysis to both reversible and irreversibly binding tracers in order to provide insight into the binding kinetics of tracer kinetics in a visual way, and some problems encountered in separating tracer delivery and binding are considered.
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About: This article is published in Nuclear Medicine and Biology. The article was published on 01 Oct 2000. and is currently open access. The article focuses on the topics: Logan plot.
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Citations
Microdosing, isotopic labeling, radiotracers and metabolomics: relevance in drug discovery, development and safety.
TL;DR: Stable or radioactive isotopes incorporated into the molecular structure of new drug entities for the purpose of pharmacokinetic or -dynamic studies find application mainly in preclinical animal investigations, whereby LC-MS/MS is used to identify metabolite structure and drug-related effects.
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Image Quantification for TSPO PET with a Novel Image-Derived Input Function Method
Yumeng Fang,Jonathan McConathy,Talene A. Yacoubian,Yue Zhang,Richard E. Kennedy,David G. Standaert +5 more
TL;DR: This IDIF provides a noninvasive alternative measurement of VT to quantify the TSPO binding of 18F-DPA-714 in the human brain through dynamic PET scans and shows superior results in distinguishing HAB from MAB subjects than VT,REF.
The quest for a better insight into physiology of fluids and barriers of the brain: the exemplary career of Joseph D. Fenstermacher
Adam Chodobski,Jean-François Ghersi-Egea,Charles Nicholson,Tavarekere N. Nagaraja,Joanna Szmydynger-Chodobska +4 more
TL;DR: Joseph D. Fenstermacher’s fundamental work on diffusion of molecules within the brain extracellular space and the research on properties of the blood–brain barrier in health and disease are described.
Non-invasive assessment of distribution volume ratios and binding potential: tissue heterogeneity and interindividually averaged time-activity curves.
Matthias Reimold,W. Mueller-Schauenburg,Georg-Alexander Becker,Gerald Reischl,Bernhard M. Dohmen,Roland Bares +5 more
TL;DR: Logan’s non-invasive method and SRTM are suitable for heterogeneous tissues and that discussion of group differences in PET studies generally should include qualitative and quantitative assessment of interindividually averaged TAC.
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Multiple linear analysis methods for the quantification of irreversibly binding radiotracers
Su Jin Kim,Jae Sung Lee,Yu Kyeong Kim,J. James Frost,Gary S. Wand,Mary E. McCaul,Dong Soo Lee +6 more
TL;DR: The two MLAIR approaches examined were found to have several advantages over the conventional GPGA method, and multiple linear analysis for irreversible radiotracer 2 parametric images showed remarkable image quality as compared with GPG a, and showed markedly improved statistical power for voxelwise comparisons.
10
References
Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data:
TL;DR: A theoretical model of blood–brain exchange is developed and a procedure is derived that can be used for graphing multiple-time tissue uptake data and determining whether a unidirectional transfer process was dominant during part or all of the experimental period.
Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Generalizations:
TL;DR: General equations are derived that can be used to analyze tissue uptake data when the blood–plasma concentration of the test substance cannot be easily measured and for situations when trapping of theTest substance is incomplete and for a combination of these two conditions.
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Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data
Jean Logan,Joanna S. Fowler,Nora D. Volkow,Nora D. Volkow,Gene-Jack Wang,Yu-Shin Ding,David Alexoff +6 more
TL;DR: In this paper, the authors proposed a graphical method for determining the distribution volume ratio (DVR), which is a linear function of receptor availability, which does not require blood sampling and is widely used as a model parameter in imaging studies.
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Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects
Jean Logan,Joanna S. Fowler,Nora D. Volkow,Alfred P. Wolf,Stephen L. Dewey,David J. Schlyer,Robert R. MacGregor,Robert Hitzemann,Bernard Bendriem,S. John Gatley,David R. Christman +10 more
TL;DR: It can be shown that, for many systems, linearity is effectively reached some time before this, and this method provides an easy, rapid method for comparison of the reproducibility of repeated measures in a single subject, for longitudinal or drug intervention protocols, or for comparing experimental results between subjects.
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Comparison of bolus and infusion methods for receptor quantitation: application to [18F]cyclofoxy and positron emission tomography.
Richard E. Carson,Michael A. Channing,Ronald G. Blasberg,Bonnie B. Dunn,Robert M. Cohen,Kenner C. Rice,Peter Herscovitch +6 more
TL;DR: An infusion protocol consisting of bolus plus continuous infusion of CF was designed and applied and has the potential to shorten scan time and simplify the acquisition and processing of scan and blood data.
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