Graphical analysis of PET data applied to reversible and irreversible tracers.
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TL;DR: In this paper, the authors apply graphical analysis to both reversible and irreversibly binding tracers in order to provide insight into the binding kinetics of tracer kinetics in a visual way, and some problems encountered in separating tracer delivery and binding are considered.
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About: This article is published in Nuclear Medicine and Biology. The article was published on 01 Oct 2000. and is currently open access. The article focuses on the topics: Logan plot.
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Citations
Receptor Databases and Computational Websites for Ligand Binding
TL;DR: Information and Uniform Resource Locators (URLs) are provided for Websites that facilitate computational and experimental studies of receptor-ligand interactions and for scientists interested in utilizing large data sets for other purposes.
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PET Imaging of Multidrug Resistance in Tumors Using 18F-Fluoropaclitaxel
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Deriving and Visualizing Uncertainty in Kinetic PET Modeling
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TL;DR: Kinetic modeling is the tool of choice when developing new positron emission tomography tracers for quantitative functional analysis and several approaches are widely used to facilitate this work.
Quantification of the glycine transporter 1 in rhesus monkey brain using [18F]MK-6577 and a model-based input function.
Sandra M. Sanabria-Bohórquez,Aniket Joshi,Marie A. Holahan,Lori Daneker,Kerry Riffel,Mangay Williams,Wenping Li,Jacquelynn J. Cook,Terence G. Hamill +8 more
TL;DR: The model-based input function method and Logan analysis are well suited for quantification of [18F]MK-6577 binding and GlyT1 occupancy in monkey brain.
11
References
Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data:
TL;DR: A theoretical model of blood–brain exchange is developed and a procedure is derived that can be used for graphing multiple-time tissue uptake data and determining whether a unidirectional transfer process was dominant during part or all of the experimental period.
Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Generalizations:
TL;DR: General equations are derived that can be used to analyze tissue uptake data when the blood–plasma concentration of the test substance cannot be easily measured and for situations when trapping of theTest substance is incomplete and for a combination of these two conditions.
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Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data
Jean Logan,Joanna S. Fowler,Nora D. Volkow,Nora D. Volkow,Gene-Jack Wang,Yu-Shin Ding,David Alexoff +6 more
TL;DR: In this paper, the authors proposed a graphical method for determining the distribution volume ratio (DVR), which is a linear function of receptor availability, which does not require blood sampling and is widely used as a model parameter in imaging studies.
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Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects
Jean Logan,Joanna S. Fowler,Nora D. Volkow,Alfred P. Wolf,Stephen L. Dewey,David J. Schlyer,Robert R. MacGregor,Robert Hitzemann,Bernard Bendriem,S. John Gatley,David R. Christman +10 more
TL;DR: It can be shown that, for many systems, linearity is effectively reached some time before this, and this method provides an easy, rapid method for comparison of the reproducibility of repeated measures in a single subject, for longitudinal or drug intervention protocols, or for comparing experimental results between subjects.
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Comparison of bolus and infusion methods for receptor quantitation: application to [18F]cyclofoxy and positron emission tomography.
Richard E. Carson,Michael A. Channing,Ronald G. Blasberg,Bonnie B. Dunn,Robert M. Cohen,Kenner C. Rice,Peter Herscovitch +6 more
TL;DR: An infusion protocol consisting of bolus plus continuous infusion of CF was designed and applied and has the potential to shorten scan time and simplify the acquisition and processing of scan and blood data.
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