Grape seed proanthocyanidin extract inhibits glutamate-induced cell death through inhibition of calcium signals and nitric oxide formation in cultured rat hippocampal neurons
Seo-Hee Ahn,Hee Jung Kim,Imju Jeong,Yi Jae Hong,Myung-Jun Kim,Duck-Joo Rhie,Yang-Hyeok Jo,Sang June Hahn,Shin Hee Yoon +8 more
TL;DR: It is suggested that GSPE inhibits 0.1 mM [Mg2+]o- and oxygen glucose deprivation-induced neurotoxicity through inhibition of calcium signals and NO formation in cultured rat hippocampal neurons.
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Abstract: Background
Proanthocyanidin is a polyphenolic bioflavonoid with known antioxidant activity. Some flavonoids have a modulatory effect on [Ca2+]i. Although proanthocyanidin extract from blueberries reportedly affects Ca2+ buffering capacity, there are no reports on the effects of proanthocyanidin on glutamate-induced [Ca2+]i or cell death. In the present study, the effects of grape seed proanthocyanidin extract (GSPE) on glutamate-induced excitotoxicity was investigated through calcium signals and nitric oxide (NO) in cultured rat hippocampal neurons.
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Jeevan K. Prasain,Ning Peng,Yanying Dai,Ray Moore,Alireza Arabshahi,Landon Wilson,Stephen Barnes,J. Michael Wyss,Helen Kim,Ray L. Watts +9 more
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