Granulocyte-macrophage colony-stimulating factor gene transcription is directly repressed by the vitamin D3 receptor. Implications for allosteric influences on nuclear receptor structure and function by a DNA element
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TL;DR: It is reported here that GMCSF transcription in Jurkat T cells is also directly repressed by 1, 25-(OH)2D3 and VDR, suggesting that VDR's action as a repressing rather than activating factor at this locus may account for its action as an allosteric effector of VDR function.
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About: This article is published in Journal of Biological Chemistry. The article was published on 24 Apr 1998. and is currently open access. The article focuses on the topics: Calcitriol receptor & Vitamin D3 Receptor.
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Citations
1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system
TL;DR: It is shown that renin expression and plasma angiotensin II production were increased severalfold in vitamin D receptor-null (VDR-null) mice, leading to hypertension, cardiac hypertrophy, and increased water intake, and 1,25(OH)(2)D(3) is a novel negative endocrine regulator of the renin-angiotens in system.
Noncalcemic Actions of Vitamin D Receptor Ligands
TL;DR: The molecular aspects of noncalcemic actions of vitamin D analogs that account for the efficacy of VDR ligands in the treatment of psoriasis, osteoporosis, and secondary hyperparathyroidism are reviewed.
Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes.
Tian-Tian Wang,Luz E. Tavera-Mendoza,David Laperrière,Eric Libby,Naomi Burton MacLeod,Yoshihiko Nagai,Véronique Bourdeau,Anna Konstorum,Benjamin Lallemant,Rui Zhang,Sylvie Mader,John H. White +11 more
TL;DR: The combined approaches used here provide numerous insights into the direct target genes underlying the broad physiological actions of 1,25(OH)2D3.
608
The coming of age of 1,25-dihydroxyvitamin D3 analogs as immunomodulatory agents
Chantal Mathieu,Luciano Adorini +1 more
TL;DR: Advances in understanding 1,25(OH)(2)D(3) functions and novel insights into the mechanisms of its immunomodulatory properties suggest a wider applicability of this hormone in the treatment of autoimmune diseases and allograft rejection.
508
1,25-Dihydroxyvitamin D3 Suppresses Renin Gene Transcription by Blocking the Activity of the Cyclic AMP Response Element in the Renin Gene Promoter
Weihua Yuan,Wei Pan,Juan Kong,Wei Zheng,Frances L. Szeto,Kari E. Wong,Ronald N. Cohen,Anna Klopot,Zhongyi Zhang,Yan Chun Li +9 more
TL;DR: Data indicate that 1,25(OH)2D3 suppresses renin gene expression at least in part by blocking the formation of CRE-CREB-CBP complex.
498
References
Isolation and characterization of the rat alpha 1(I) collagen promoter. Regulation by 1,25-dihydroxyvitamin D.
TL;DR: These experiments indicate that the alpha 1(I) promoter contains cis-active elements which are regulated by the 1,25-(OH)2D3 receptor in ROS 17/2.8 cells.
Regulatory crosstalk at composite response elements
TL;DR: Transcriptional regulatory factors from different families interact with each other when bound to DNA at composite response elements, and closely related factors from a given family can produce very different regulatory patterns.
Regulation of lymphokine production and human T lymphocyte activation by 1,25-dihydroxyvitamin D3. Specific inhibition at the level of messenger RNA.
TL;DR: Data indicate that calcitriol regulated proteins associated with T cell activation at the transcriptional level and that these effects were mediated in a specific, coordinate fashion.
Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction.
TL;DR: It is shown that translocation requires two redundant nuclear localization sequences and that one sequence is in an intramolecular association with phosphorserines in a conserved motif located at the amino terminus of each NF-AT protein.
1 alpha,25-Dihydroxyvitamin D3 inhibits gamma-interferon synthesis by normal human peripheral blood lymphocytes.
TL;DR: 1 alpha,25-Dihydroxyvitamin D3 [1,25-(OH)2D3], the biologically active metabolite of vitamin D3, inhibited synthesis of gamma-interferon (IFN-gamma) by phytohemagglutinin-activated peripheral blood lymphocytes (PBLs).