Granulocyte-macrophage colony-stimulating factor gene transcription is directly repressed by the vitamin D3 receptor. Implications for allosteric influences on nuclear receptor structure and function by a DNA element
108
TL;DR: It is reported here that GMCSF transcription in Jurkat T cells is also directly repressed by 1, 25-(OH)2D3 and VDR, suggesting that VDR's action as a repressing rather than activating factor at this locus may account for its action as an allosteric effector of VDR function.
read more
About: This article is published in Journal of Biological Chemistry. The article was published on 24 Apr 1998. and is currently open access. The article focuses on the topics: Calcitriol receptor & Vitamin D3 Receptor.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Leprosy and the Human Genome
TL;DR: Identifying and functionally exploring the genetic and immunological factors that underlie human susceptibility to leprosy have yielded important insights into M. leprae pathogenesis and are likely to advance the understanding of the immune response to other pathogenic mycobacteria.
124
Vitamin D3 alters microglia immune activation by an IL-10 dependent SOCS3 mechanism
TL;DR: Vitamin D3 increases the expression of IL-10 creating a feedback loop via SOCS3 that downregulates the pro-inflammatory immune response by activated microglia which would likewise prevent immune mediated damage in the CNS.
101
Vitamin D signaling in immune-mediated disorders: Evolving insights and therapeutic opportunities.
TL;DR: This review aims to summarize the data as they stand at the present time on the role of vitamin D in the pathogenesis of immune-mediated disorders, with special focus on type 1 diabetes, and on the therapeutic opportunities for vitaminD in the prevention and treatment of this autoimmune disease in mouse models and humans.
99
A two-hit mechanism for vitamin D3-mediated transcriptional repression of the granulocyte-macrophage colony-stimulating factor gene: vitamin D receptor competes for DNA binding with NFAT1 and stabilizes c-Jun.
TL;DR: The mechanism by which VDR elicits its transcriptional inhibitory effect is described, which effectively block the NFAT1–AP-1 activation complex, resulting in an attenuation of activated GM-CSF transcription.
95
Estrogen response element sequence impacts the conformation and transcriptional activity of estrogen receptor alpha.
Carolyn M. Klinge,Sarah C. Jernigan,Stacy L. Smith,Valentyn V. Tyulmenkov,Peter C. Kulakosky +4 more
TL;DR: The results support the hypothesis that the ERE sequence acts as an allosteric effector, altering ER conformation, and speculate that ERE-induced alterations in ERalpha conformation modulate interaction with co-regulatory proteins.
94
References
Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors.
TL;DR: This study points to the general importance of tandem repeat hormone response elements and suggests a simple physiologic code exists in which half-site spacing plays a critical role in achieving selective hormonal response.
1.7K
Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction
Hsin-Fang Yang-Yen,Jean-Claude Chambard,Yu-Lin Sun,Tod Smeal,Thomas J. Schmidt,Jacques Drouin,Michael Karin +6 more
TL;DR: Findings reveal a cross talk between two major signal transduction systems used to control gene transcription in response to extracellular stimuli, and a novel mechanism for transcriptional repression.
1.6K
Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor
Roland Schule,Pundl Rangarajan,Steven A. Kliewer,Lynn J. Ransone,Jack Bolado,Na Yang,Na Yang,Inder M. Verma,Ronald M. Evans +8 more
TL;DR: Evidence is presented that the glucocorticoid receptor (GR) and transcription factor Jun/AP-1 can reciprocally repress one another's transcriptional activation by a novel mechanism that is independent of DNA binding.
1.3K
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha.
TL;DR: The crystal structure of the human retinoid-X receptor RXR-α ligand-binding domain reveals a previously undiscovered fold of an antiparallel α-helical sandwich, packed as dimeric units.
1.2K
Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3
Etsuko Abe,Chisato Miyaura,Hiroshi Sakagami,Minoru Takeda,Kunio Konno,Tohru Yamazaki,Shusaku Yoshiki,Tatsuo Suda +7 more
TL;DR: The results suggest the possibility that, in addition to its wellknown biological activities in enhancing intestinal calcium transport and bone mineral mobilization, 1 alpha, 25-dihydroxyvitamin D3 is involved in the differentiation of bone marrow cells.
1K