Journal Article10.1056/NEJM199103073241005
Graft-versus-host disease
James L.M. Ferrara,H. J. Deeg +1 more
1.2K
About: This article is published in The New England Journal of Medicine. The article was published on 07 Mar 1991. The article focuses on the topics: Transplantation & Immunopathology.
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Citations
Graft-versus-host disease
TL;DR: The understanding of the risk factors and causes of GHVD, the cellular and cytokine networks implicated in its pathophysiology, and current strategies to prevent and treat the disease are reviewed.
2.3K
Posaconazole or fluconazole for prophylaxis in severe graft-versus-host disease
Andrew J. Ullmann,Jeffrey H. Lipton,David H. Vesole,Pranatharthi H. Chandrasekar,Amelia Langston,Stefano R. Tarantolo,Hildegard Greinix,Wellington Morais de Azevedo,Vijay Reddy,Navdeep Boparai,Lisa D. Pedicone,Hernando Patino,Simon Durrant +12 more
TL;DR: Posaconazole was similar to fluconazole for prophylaxis against fungal infections among patients with GVHD and was superior in preventing invasive aspergillosis and reducing the rate of deaths related toFungal infections.
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Management of severe perioperative bleeding Guidelines from the European Society of Anaesthesiology
Sibylle A. Kozek-Langenecker,Arash Afshari,Pierre Albaladejo,Cesar Aldecoa Alvarez Santullano,Edoardo De Robertis,Daniela Filipescu,Dietmar Fries,Thorsten Haas,Georgina Imberger,Matthias Jacob,Marcus D. Lancé,Juan V. Llau,Susan Mallett,Jens Meier,Niels Rahe-Meyer,Charles Marc Samama,Andrew Smith,Cristina Solomon,Philippe Van der Linden,Anne Wikkelsø,Patrick Wouters,Piet Wyffels +21 more
TL;DR: These guidelines are intended to provide an overview of current knowledge on the subject with an assessment of the quality of the evidence in order to allow anaesthetists throughout Europe to integrate this knowledge into daily patient care wherever possible.
976
Chronic graft-versus-host disease.
TL;DR: Chronic graft versus host disease (GvHD) continues to be a significant problem in the allogeneic stem cell transplant setting and, as the authors continue to use alternative stem cell sources and attempt to modulate the immune system to increase an anti-tumour effect, they will probably see rising numbers of patients with this complication.
949
The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation
TL;DR: Experimental approaches to the prevention of GVHD include reducing the damage to the GI tract by fortification of the GI mucosal barrier through novel "cytokine shields" such as IL-11 or keratinocyte growth factor, and they now deserve formal testing in carefully designed clinical trials.
745
References
Development of graft-vs.-host disease-like syndrome in cyclosporine-treated rats after syngeneic bone marrow transplantation. I. Development of cytotoxic T lymphocytes with apparent polyclonal anti-Ia specificity, including autoreactivity.
TL;DR: Results suggested that the anti-class II autoreactive cell associated with syngeneic GVHD either recognizes a common class II determinant ("public" epitope) shared by multiple strains of rats, or was polyspecific with respect to "private" class IIeterminants.
Treatment of corticosteroid resistant acute graft-versus-host disease by in vivo administration of anti-interleukin-2 receptor monoclonal antibody (B-B10)
Patrick Hervé,John Wijdenes,J.P. Bergerat,Pierre Bordigoni,Noel-Jean Milpied,Jean-Yves Cahn,C Clement,R Beliard,B. Morel-Fourrier,Evelyne Racadot +9 more
TL;DR: There was, however, a significant correlation between the clinical response and the B-B10 kinetics as a function of time: serum B- B10 levels attained a plateau level more rapidly in the CR group than in the PR/NR group.
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Graft rejection and graft-versus-host disease: mirror images.
TL;DR: Attempts to suppress graft rejection or GvHD are likely to increase the reciprocal outcomes unless additional measures are instituted, and these events are inversely correlated.
123
•Journal Article
Clonal analysis of murine graft-vs-host disease. I. Phenotypic and functional analysis of T lymphocyte clones.
TL;DR: The presence of I-Ab-specific T lymphocytes with a phenotype identical to CG clones early after transplantation suggests that the immunologic events that result in chronic GVHD begin soon after transplant, indicating that acute GV HD is due primarily to recipient-specific cytotoxic donor T lymphocyte, whereas chronic GvHD is due to autoreactive helper T lymph cells.
114
T cell depletion for graft-versus-host-disease prophylaxis: a perspective on engraftment in mice and humans
TL;DR: Dans l'etat actuel des connaissances cliniques une attitude precautionneuse et frequente vis-a-vis de la depletion en cellules T, mais les resultats a long terme semblent plus importants que les desavantages transitoires.
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