Gonadotropin-releasing hormone signaling: An information theoretic approach

TL;DR: A variety of modeling approaches are described to investigate the questions raised by some of the most striking features of the HPG axis, including the pulsatile secretion of hypothalamic and pituitary hormones and its counterpart, the cell signaling induced by frequency-encoded hormonal signals.

TL;DR: It is postulated that TCAP represents an ancient peptide that mediates intercellular information transfer of stressful and noxious events by regulating energy utilization among neurons.

TL;DR: This study reveals an essential role of AR-YAP1 in the regulation of PCa cell migration, and provides evidence that GV1001 could be a novel GnRHR ligand to inhibit metastasis ofPCa via the Gas/cAMP pathway.

TL;DR: The issue starts with an article introducing multiple signaling pathways accounting for central and peripheral control of secretory pituitary cells in human and non-humanprimates and the roles of melatonin and cortistatin in control of pituitsary functions.

TL;DR: The pubertal transition to adulthood involves both gonadal and behavioral maturation, and reproductive maturity is the product of developmentally timed, brain-driven and recurrent interactions between steroid hormones and the adolescent nervous system.

TL;DR: It is concluded that each pulsatile LH secretory episode results from a pulsatile discharge of GnRH from the hypothalamus via the portal network.

TL;DR: The data suggest that β-arrestins function both as scaffolds to enhance cRaf-1 and MEK-dependent activation of ERK2, and as targeting proteins that direct activated ERK to specific subcellular locations.

TL;DR: Delineation of the structural elements in GnRH and the receptor, which facilitate differential signaling, will contribute to the development of novel interventive GnRH analogs.