Gold catalysis in total synthesis—an update

TL;DR: In this article, the formation of a bench-stable neutral IPrCl-gold(I) tetrafluoroborate complex is reported, and experimental studies by X-ray diffraction analysis and NMR spectroscopy and theoretical studies by DFT calculations are conducted to determine the composition, structure, and behavior of this complex.

TL;DR: In this paper, a coumarin-alkyne derivative (NC7-AL) was developed to specifically react with Au3+ and give a colorimetric and fluorescent response toward Au3+.

TL;DR: In this paper, a simple and efficient strategy for the construction of 6-aza/oxa-spiro[4.5]decane skeletons under the cocatalysis of gold( I)/copper(II) was developed, and its potential utility was demonstrated by a formal synthesis of biologically active marine alkaloid (+/-)-halichlorine.

TL;DR: In this paper, metal-bound isobenzopyrylium species are proposed as reactive intermediates in transition-metal-catalyzed cyclizations of o-alkynylbenzaldehydes (enynals) or o-ALKynylarylketones.

TL;DR: Important vinylgold intermediates, the transmetalation from gold to other transition metals, the development of new ligands for gold catalysis, and significant contributions from computational chemistry are other crucial points for the field highlighted here.

TL;DR: The ways in which selectivity can be controlled in homogeneous Au catalysis are enumerated, in the hope that lessons to guide catalyst selection and the design of new catalysts may be distilled from a thorough evaluation of ligand, counterion, and oxidation state effects as they influence chemo-, regio-, and stereoselectivity in homogeneity AuCatalysis.

TL;DR: Thanks to gold-based catalysts, various organic transformations have been accessible under facile conditions with both high yields and chemoselectivity.

TL;DR: The results show clear trends in gold-Catalyzed C-H Bond Functionalization and Selective Reductions, and catalytic Hydrogenation of Alkenes and 1,3-Dienes, as well as in other areas of science.