Journal Article10.1039/C1CS15279C
Gold catalysis in total synthesis—an update
958
TL;DR: In this critical review, the strongly increasing amount of new applications of gold catalysis in total synthesis is summarised and, for the new developed methods, the mode of activation of the substrate by the gold catalyst is discussed.
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Abstract: In this critical review, the strongly increasing amount of new applications of gold catalysis in total synthesis is summarised and, for the new developed methods, the mode of activation of the substrate by the gold catalyst is discussed (47 references).
read more
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Citations
Gold-Catalyzed Cycloisomerization of 1,7-Enyne Esters to Structurally Diverse cis-1,2,3,6-Tetrahydropyridin-4-yl Ketones
TL;DR: The utility of this piperidine forming strategy as a synthetic tool that makes use of 1,7-enyne esters was exemplified by its application to the synthesis of an enantiopure analogue of the bioactive 2,3,4,4a,5,9b-hexahydroindeno[1,2-c]pyridine family of compounds.
61
Gold(I)-Catalyzed 6-endo-Dig Hydrative Cyclization of an Alkyne-Tethered Ynamide: Access to 1,6-Dihydropyridin-2(3H)ones
TL;DR: In this paper, Echavarren's catalyst and p-toluenesulphonic acid (PTSA) at room temperature affords an array of 1,6-dihydropyridin-2(3H)one derivatives.
61
Goldkatalysierte C-H-Anellierung von Anthranilen mit Alkinen: flexible, atomökonomische Synthese ungeschützter 7-Acylindole
Hongming Jin,Long Huang,Jin Xie,Matthias Rudolph,Frank Rominger,A. Stephen K. Hashmi,A. Stephen K. Hashmi +6 more
TL;DR: In this article, a goldkatalysierte C-H-Anellierung of Anthranilderivaten with Alkinen eroffnet eine einfache, flexible and atomokonomische einstufige Route zu ungeschutzten 7-Acylindolen.
61
Gold(I)‐Catalyzed Dearomative [2+2]‐Cycloaddition of Indoles with Activated Allenes: A Combined Experimental–Computational Study
Riccardo Ocello,Assunta De Nisi,Minqiang Jia,Qing-Qing Yang,Magda Monari,Pietro Giacinto,Andrea Bottoni,Gian Pietro Miscione,Gian Pietro Miscione,Marco Bandini +9 more
TL;DR: The computational (DFT) investigation has fully elucidated the reaction mechanism providing clear evidence for a two-step reaction, and two parallel reaction pathways explain the regioisomeric products obtained under kinetic and thermodynamic conditions.
61
Gold for the Generation and Control of Fluxional Barbaralyl Cations
Paul R. McGonigal,Claudia de León,Yahui Wang,Anna Homs,César R. Solorio-Alvarado,Antonio M. Echavarren +5 more
TL;DR: Gold-catalyzed cycloisomerizations of 7-alkynyl cyclohepta-1,3,5-trienes were found to proceed via fluxional barbaralyl intermediates, which could be controlled by the choice of gold complex.
60
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