Journal Article10.1016/0309-1651(82)90125-4
Glycolysis, glutaminolysis and cell proliferation
314
TL;DR: Several important recent observations using isolated cells in culture have shed more light on the role of glucose metabolism in normal and abnormal cell proliferation and in the expression of the malignant cell phenotype.
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About: This article is published in Cell Biology International Reports. The article was published on 01 Jul 1982. The article focuses on the topics: Anaerobic glycolysis & Glutaminolysis.
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Citations
Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
TL;DR: In this paper, the authors provide a detailed accounting of the biosynthetic requirements to construct a new cell and illustrate the importance of glycolysis in providing carbons to generate biomass.
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Acid pH in Tumors and Its Potential for Therapeutic Exploitation
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Pyruvate kinase type M2 and its role in tumor growth and spreading
TL;DR: The switch between the tetrameric and dimeric form of M2-PK allows tumor cells to survive in environments with varying oxygen und nutrient supply.
842
Is Glutamine a Conditionally Essential Amino Acid
TL;DR: Provision of supplemental glutamine in specialized enteral or parenteral feeding may enhance nutritional management and augment recovery of the seriously ill while minimizing hospital stay.
833
Regulation of mammalian nucleotide metabolism and biosynthesis
Andrew N. Lane,Teresa W.-M. Fan +1 more
TL;DR: The cellular demands of nucleotide biosynthesis, their metabolic pathways and mechanisms of regulation during the cell cycle are reviewed and how this may lead to potential new approaches to drug development in diseases such as cancer is discussed.
References
Uptake and Metabolism of Plasma Glutamine by the Small Intestine
TL;DR: In this paper, an isolated, vascularly perfused preparation of rat intestine extracted large amounts of glutamine (75 µmoles per hour), but no other amino acid, from a recirculated blood perfusate.
796
Uptake and Metabolism of Plasma Glutamine by the Small Intestine
TL;DR: The results of these studies suggest that glutamine derived from blood is an important respiratory substrate for cells in the small intestinal mucosa and that intestine is a major site for metabolism of glutamine released into the circulation by other tissues.
659
•Book
Growth, nutrition, and metabolism of cells in culture
George H. Rothblatt,Vincent J. Cristofalo +1 more
- 01 Jan 1972
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