Journal Article10.1016/0166-2236(89)90042-8
Glycine modulation of the NMDA receptor/channel complex
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TL;DR: A new property of this receptor/channel complex has recently emerged: its activation is greatly enhanced by and may even be dependent on, sub-micromolar concentrations of glycine.
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About: This article is published in Trends in Neurosciences. The article was published on 01 Jan 1989. The article focuses on the topics: Glycine receptor & NMDA receptor.
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References
Glycine potentiates the NMDA response in cultured mouse brain neurons
J. W. Johnson,P Ascher +1 more
TL;DR: G glycine may facilitate excitatory transmission in the brain through an allosteric activation of the NMDA receptor, and can be observed in outside-out patches as an increase in the frequency of opening of the channels activated by NMDA agonists.
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Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes
TL;DR: In voltage-clamped oocytes, neither perfusion nor rapid pressure application of NMDA onto messenger RNA-injected oocytes caused a distinct ionic current without added glycine, but when glycine was added, NMDA evoked large inward currents.
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A glycine site associated with N-methyl-D-aspartic acid receptors: characterization and identification of a new class of antagonists.
TL;DR: Kynurenate‐type compounds inhibit glycine binding and are suggested to form a novel class of antagonists of the NMDA receptor acting through the glycine site, suggesting the existence of a dual and opposite modulation of NMDA receptors by endogenous ligands.
766
Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons
TL;DR: The ability of zinc to specifically modulate postsynaptic neuronal responses to excitatory amino acid transmitters, reducing N-methyl-to-aspartate receptor-mediated excitation while often increasing quisqualate receptor's excitation, is proposed to underlie its normal function at central exciteatory synapses and furthermore could be relevant to neuronal cell loss in certain disease states.
706
Regulation of NMDA receptor desensitization in mouse hippocampal neurons by glycine
TL;DR: Using a fast perfusion system, glycine regulates desensitization at NMDA receptors; this has a major effect on the response to NMDA measured at equilibrium, as would occur with slower applications of agonist.
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