Journal Article10.1016/J.JCONREL.2011.01.030
Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery.
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TL;DR: This paper will review recent results on GSH-responsive nano-vehicles in particular micelles, nanoparticles, capsules, polymersomes, nanogels, dendritic and macromolecular drug conjugates, and nano-sized nucleic acid complexes for controlled delivery of anti-cancer drugs and nucleic acids.
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About: This article is published in Journal of Controlled Release. The article was published on 30 May 2011. The article focuses on the topics: Drug carrier & Gene delivery.
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Citations
Tumor-mediated shape-transformable nanogels with pH/redox/enzymatic-sensitivity for anticancer therapy
Dong Zhou,Sainan Liu,Yongjun Hu,Shiwei Yang,Bing Zhao,Kaikai Zheng,Yuhong Zhang,Peixin He,Guoyan Mo,Yulin Li +9 more
TL;DR: Researchers developed tumor-mediated nanogels that transform from 100-200 nm to 4 nm in size in response to tumor microenvironments, enhancing therapeutic delivery and antitumor efficacy through selective administration of charged drugs.
Redox-Sensitive Materials for Drug Delivery: Targeting the Correct Intracellular Environment, Tuning Release Rates, and Appropriate Predictive Systems
TL;DR: A strong case can be made for the use of biorelevant reducing agents such as glutathione when demonstrating a materials redox response, and to ensure these materials can be advanced beyond simple "on/off" systems.
Reduction-responsive dithiomaleimide-based nanomedicine with high drug loading and FRET-indicated drug release
TL;DR: Dithiomaleimide-based camptothecin-containing nanoparticles are designed to have exceptionally high drug loading and are capable of reduction-responsive, FRET-indicated drug release.
Evaluation on redox-triggered degradation of thioether-bridged hybrid mesoporous organosilica nanoparticles
TL;DR: In this article, the degradation behavior of colloidal mesoporous silica (CMS) and HCMS nanoparticles in the medium were compared to evaluate the degradability of hybrid organosilica carriers with different contents of doped thioether bonds.
Bioresponsive nanomedicines based on dynamic covalent bonds
TL;DR: In this article, the authors focus on responsive nanomedicines containing dynamic chemical bonds that can be cleaved by various specific stimuli, enabling achievement of targeted drug release for optimal therapy in various diseases.
References
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Biodegradable polymeric nanoparticles as drug delivery devices
TL;DR: This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems from 1990 through mid-2000.
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Block copolymer micelles for drug delivery: design, characterization and biological significance
TL;DR: The utility of polymeric micelles formed through the multimolecular assembly of block copolymers as novel core-shell typed colloidal carriers for drug and gene targeting and their feasibility as non-viral gene vectors is highlighted.
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Biodegradable nanoparticles for drug and gene delivery to cells and tissue
Jayanth Panyam,Vinod Labhasetwar +1 more
TL;DR: Based on the above mechanism, various potential applications of nanoparticles for delivery of therapeutic agents to the cells and tissue are discussed.
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