Journal Article10.1016/J.JCONREL.2011.01.030
Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery.
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TL;DR: This paper will review recent results on GSH-responsive nano-vehicles in particular micelles, nanoparticles, capsules, polymersomes, nanogels, dendritic and macromolecular drug conjugates, and nano-sized nucleic acid complexes for controlled delivery of anti-cancer drugs and nucleic acids.
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About: This article is published in Journal of Controlled Release. The article was published on 30 May 2011. The article focuses on the topics: Drug carrier & Gene delivery.
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Citations
Studies on preparations and pH/redox responsiveness of zwitterionic nanomicelles of poly[lysine-co-N,N-bis(acryloyl)cystamine-co-dodecylamine]
TL;DR: In this paper, the authors synthesized poly[L-lysine-co-N,N-bis(acryloyl) cystamine-co,dodecylamine] nanomicelles (NMs) through Michael addition terpolymerization in one pot.
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Development of a novel sialic acid-conjugated camptothecin prodrug for enhanced cancer chemotherapy.
TL;DR: For the first time, 9-thiol-sialic acid is coupled to CPT by forming a disulfide releasable carbonate linkage, resulting in a novel CPT prodrug (CPT-ss-Sia) that self-assembles into nanostructures in an aqueous solution that exhibited excellent in vitro properties.
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A Simple Synthesis of Reduction-Responsive Acrylamide-Type Nanogels for miRNA Delivery
TL;DR: In this article , acrylamide-based nanogels containing cationic groups and redox-sensitive crosslinkers were developed for cellular delivery of anti-miR21 (a-MIR21).
Perfluorocarbon Nanodroplets for Dual Delivery with Ultrasound/GSH-Responsive Release of Model Drug and Passive Release of Nitric Oxide
TL;DR: The preliminary results demonstrate that the approach is versatile and can be extended to not only GSH-responsive but also other stimuli- responsive block copolymers, thereby allowing for the fabrication of broad choices of stimuli-responsive PFC-nanodroplets in aqueous solution for dual delivery of drug and NO therapeutics.
Multidimensional profiling of functionalized photothermal nanoplatforms for synergistic cancer immunotherapy: Design, strategy, and challenge
Xiao Fan Wei,Mingzhu Song,Guanghao Jin,Wenyue Jia,Jing Wang,Min Liang,Liang Zou +6 more
TL;DR: This review discusses the design and challenges of functionalized photothermal nanoplatforms for synergistic cancer immunotherapy, highlighting the need for multidimensional profiling to overcome biological delivery barriers and enhance immune response in the tumor microenvironment.
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