Journal Article10.1016/J.JCONREL.2011.01.030
Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery.
1.2K
TL;DR: This paper will review recent results on GSH-responsive nano-vehicles in particular micelles, nanoparticles, capsules, polymersomes, nanogels, dendritic and macromolecular drug conjugates, and nano-sized nucleic acid complexes for controlled delivery of anti-cancer drugs and nucleic acids.
read more
About: This article is published in Journal of Controlled Release. The article was published on 30 May 2011. The article focuses on the topics: Drug carrier & Gene delivery.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Thiol-responsive hydrogel scaffolds for rapid change in thermoresponsiveness
TL;DR: Thiol-responsive cleavage of disulfide linkages to the corresponding pendant thiols allows for the generation of hydrophilic dangling chains in the hydrogels as well as the increase in hydrophilicity of the Hydrogel network.
11
Doxorubicin-Bound Hydroxyethyl Starch Conjugate Nanoparticles with pH/Redox Responsive Linkage for Enhancing Antitumor Therapy.
TL;DR: In this article, a novel type of conjugate was synthesized using hydroxyethyl starch (HES) as a carrier while binding doxorubicin (DOX) onto HES backbone through a pH/redox responsive linker containing both disulfide and hydrazone bonds in series.
pH and Reduction Dual-Responsive Nanogels as Smart Nanocarriers to Resist Doxorubicin Aggregation
TL;DR: P pH/reduction dual-responsive nanogels show promise as drug delivery systems for anticancer therapy and enhance the release of doxorubicin hydrochloride (DOX) in conditions characteristic of the cancer microenvironment.
Optimization and Characterization of Protein Nanoparticles for the Targeted and Smart Delivery of Cytochrome c to Non-Small Cell Lung Carcinoma.
Vanessa Barcelo-Bovea,Irivette Dominguez-Martinez,Freisa Joaquin-Ovalle,Luis A. Amador,Elizabeth Castro-Rivera,Kristofer Medina-Alvarez,Anthony J. McGoron,Kai Griebenow,Yancy Ferrer-Acosta +8 more
TL;DR: A drug delivery system consisting of Cyt c nanoparticles decorated with folate-poly(ethylene glycol)-poly(lactic-co-glycolic acid)-thiol (FA-PEG-PLGA-SH) to deliverCyt c into cancer cells and proves to be thrice as selective towards cancerous than normal cells.
11
Dual-responsive click-crosslinked micelles designed for enhanced chemotherapy for solid tumors
TL;DR: This study highlights the design of clickable block copolymers to easily construct core-crosslinked and multiple stimuli-responsive micelles for enhanced anticancer therapy.
11
References
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.
TL;DR: Estimates can be used to more fully understand the redox biochemistry that results from oxidative stress, which hopefully will provide a rationale and understanding of the cellular mechanisms associated with cell growth and development, signaling, and reductive or oxidative stress.
4.6K
Biodegradable polymeric nanoparticles as drug delivery devices
TL;DR: This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems from 1990 through mid-2000.
3.7K
Glutathione Metabolism and Its Implications for Health
TL;DR: Animal and human studies demonstrate that adequate protein nutrition is crucial for the maintenance of GSH homeostasis, and compelling evidence shows that GSH synthesis is regulated primarily by gamma-glutamylcysteine synthetase activity, cysteine availability, and GSH feedback inhibition.
Block copolymer micelles for drug delivery: design, characterization and biological significance
TL;DR: The utility of polymeric micelles formed through the multimolecular assembly of block copolymers as novel core-shell typed colloidal carriers for drug and gene targeting and their feasibility as non-viral gene vectors is highlighted.
3.7K
Biodegradable nanoparticles for drug and gene delivery to cells and tissue
Jayanth Panyam,Vinod Labhasetwar +1 more
TL;DR: Based on the above mechanism, various potential applications of nanoparticles for delivery of therapeutic agents to the cells and tissue are discussed.
3.5K