Journal Article10.1016/J.JCONREL.2011.01.030
Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery.
1.2K
TL;DR: This paper will review recent results on GSH-responsive nano-vehicles in particular micelles, nanoparticles, capsules, polymersomes, nanogels, dendritic and macromolecular drug conjugates, and nano-sized nucleic acid complexes for controlled delivery of anti-cancer drugs and nucleic acids.
read more
About: This article is published in Journal of Controlled Release. The article was published on 30 May 2011. The article focuses on the topics: Drug carrier & Gene delivery.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Redox‐responsive gene delivery from perfluorocarbon nanoemulsions through cleavable poly(2‐oxazoline) surfactants
TL;DR: In this paper, the authors employ cleavable poly(2-oxazoline) diblock copolymer surfactants to form perfluorocarbon (PFC) nanoemulsions that release cargo upon exposure to glutathione.
21
Reduction-Sensitive Dextran-Paclitaxel Polymer-Drug Conjugate: Synthesis, Self-Assembly into Nanoparticles, and In Vitro Anticancer Efficacy.
TL;DR: In this paper, a reduction-sensitive polymer-drug conjugate (Dex-SS-PTXL) was developed to self-assemble into spherical NPs with an average size of 110 ± 34 nm and a ζ-potential of -14.09 ± 8 mV.
21
Genetic, reproductive and oxidative damage in mice triggered by co-exposure of nanoparticles: From a hypothetical scenario to a real concern
Okunola A. Alabi,Okunola A. Alabi,Adny Henrique Silva,Louise Rubia Probst Purnhagen,Gabriela Regina Rosa Souza,Leônidas João de Mello Junior,Fabíola Branco Filippin-Monteiro,Milene Dalmina,Frederico Pittella,Adekunle Akanji Bakare,Tânia Beatriz Creczynski-Pasa +10 more
TL;DR: It is shown, for the first time, that co-exposure to SPIONs and SLNs is more genotoxic to somatic and germ cells than their individual exposure.
20
Dual-sensitive and folate-conjugated mixed polymeric micelles for controlled and targeted drug delivery
TL;DR: The cytotoxicity tests against FA-positive (HeLa) and FA-negative (HT-29) tumor cell lines suggest that this mixed polymeric micelle system has potential merits as a controlled and targeted drug delivery system.
20
A traceless linker for aliphatic amines that rapidly and quantitatively fragments after reduction.
Maomao He,Jie Li,Hesong Han,Clarissa A. Borges,Gabriel Neiman,Joachim Justad Røise,Piotr Hadaczek,Rima Mendonsa,Victoria R Holm,Ross C. Wilson,Krystof S. Bankiewicz,Yumiao Zhang,Yumiao Zhang,Corinne M. Sadlowski,Kevin E. Healy,Lee W. Riley,Niren Murthy +16 more
TL;DR: Dec was able to reversibly modify the lysine residues on CRISPR–Cas9 with either PEG, the cell penetrating peptide Arg10, or donor DNA, and generated Cas9 conjugates with significantly improved biological properties, making it a more suitable candidate for genome editing in animals.
References
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.
TL;DR: Estimates can be used to more fully understand the redox biochemistry that results from oxidative stress, which hopefully will provide a rationale and understanding of the cellular mechanisms associated with cell growth and development, signaling, and reductive or oxidative stress.
4.6K
Biodegradable polymeric nanoparticles as drug delivery devices
TL;DR: This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems from 1990 through mid-2000.
3.7K
Glutathione Metabolism and Its Implications for Health
TL;DR: Animal and human studies demonstrate that adequate protein nutrition is crucial for the maintenance of GSH homeostasis, and compelling evidence shows that GSH synthesis is regulated primarily by gamma-glutamylcysteine synthetase activity, cysteine availability, and GSH feedback inhibition.
Block copolymer micelles for drug delivery: design, characterization and biological significance
TL;DR: The utility of polymeric micelles formed through the multimolecular assembly of block copolymers as novel core-shell typed colloidal carriers for drug and gene targeting and their feasibility as non-viral gene vectors is highlighted.
3.7K
Biodegradable nanoparticles for drug and gene delivery to cells and tissue
Jayanth Panyam,Vinod Labhasetwar +1 more
TL;DR: Based on the above mechanism, various potential applications of nanoparticles for delivery of therapeutic agents to the cells and tissue are discussed.
3.5K