Journal Article10.1016/J.JCONREL.2011.01.030
Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery.
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TL;DR: This paper will review recent results on GSH-responsive nano-vehicles in particular micelles, nanoparticles, capsules, polymersomes, nanogels, dendritic and macromolecular drug conjugates, and nano-sized nucleic acid complexes for controlled delivery of anti-cancer drugs and nucleic acids.
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About: This article is published in Journal of Controlled Release. The article was published on 30 May 2011. The article focuses on the topics: Drug carrier & Gene delivery.
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Citations
Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies
Hailong Tian,Tingting Zhang,Siyuan Qin,Zhao Huang,Li Zhou,Jia-Zhen Shi,Edouard C. Nice,Nancy Xie,Canhua Huang,Zhisen Shen +9 more
TL;DR: In this paper , the authors comprehensively summarize the field of active targeting drug delivery systems and a number of stimuli-responsive release studies in the context of emerging nanoplatform development, and also discuss how this knowledge can contribute to further improvements in clinical practice.
Dual-stimuli responsive hyaluronic acid-conjugated mesoporous silica for targeted delivery to CD44-overexpressing cancer cells
Qinfu Zhao,Jia Liu,Wenquan Zhu,Changshan Sun,Donghua Di,Ying Zhang,Pu Wang,Zhanyou Wang,Siling Wang +8 more
TL;DR: The development of an effective method for using a single substance as multi-functional material for MSN to simultaneously regulate drug release and achieve targeted delivery is described.
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Co-delivery of chemotherapeutics and proteins for synergistic therapy.
TL;DR: The co-delivery systems result in markedly enhanced blood stability and in vivo half-lives of the small drugs and proteins, elevated tumor accumulation, as well as the capability of delivering the multiple agents to the same target sites with rational drug/protein ratios, which may facilitate maximizing the synergistic effects and therefore lead to optimal antitumor efficacy.
208
Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach
Ghanbar Mahmoodi Chalbatani,Hassan Dana,Hassan Dana,Elahe Gharagouzloo,Santiago Grijalvo,Ramon Eritja,Craig D. Logsdon,Fereidoon Memari,Seyed Rouhollah Miri,Mahdi Rezvani Rad,Vahid Marmari +10 more
TL;DR: The progress of siRNA therapy as well as its medical application via nanoparticle-mediated delivery for cancer treatment are discussed.
Nanogel: A Versatile Nano-Delivery System for Biomedical Applications
TL;DR: The targeted delivery of therapeutic agents, as well as the combinational therapy strategy, result in the improved efficacy of disease treatments, though the introduction of a multifunctional nanogel-based drug delivery system.
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