Glutaminolysis and Transferrin Regulate Ferroptosis.
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TL;DR: Inhibition of glutaminolysis, the essential component of ferroptosis, can reduce heart injury triggered by ischemia/reperfusion, suggesting a potential therapeutic approach for treating related diseases.
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About: This article is published in Molecular Cell. The article was published on 16 Jul 2015. and is currently open access. The article focuses on the topics: Glutaminolysis & Transferrin receptor.
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Citations
Understanding the unique mechanism of ferroptosis: a promising therapeutic target
Yuanyuan Kong,Jing Li,Shifeng Lu,Liucheng Rong,Yao Xue,Yongjun Fang +5 more
TL;DR: Understanding the unique mechanism of ferroptosis is a review on the molecular mechanisms underlying this form of regulated cell death. The review highlights the distinct characteristics of ferroptosis, including high intracellular lipid peroxide and redox imbalance, and discusses the molecular pathways that modulate ferroptosis.
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The underlying pathological mechanism of ferroptosis in the development of cardiovascular disease
TL;DR: Molecular mechanisms concerned are summarized systematically and categorized to depict the regulatory network of ferroptosis and point out potential therapeutic targets for diverse cardiovascular disorders.
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Decoding ferroptosis: Revealing the hidden assassin behind cardiovascular diseases.
Zeyu Zhang,Zhihua Yang,Xianliang Wang,Jingyuan Mao +3 more
- 23 May 2024
TL;DR: This review decodes ferroptosis, an iron-dependent cell death process, and its role in cardiovascular diseases, highlighting its mechanisms, similarities with traditional cell death modes, and therapeutic potential in various CVDs, including coronary heart disease and pulmonary hypertension.
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TL;DR: In this paper, the chemical nature of the antioxidant is known and a test specific for the compound or group of interest; for example, the nitroprusside test for sulphydryl groups.
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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Scott J. Dixon,Kathryn M. Lemberg,Michael R. Lamprecht,Rachid Skouta,Eleina M. Zaitsev,Caroline E Gleason,Darpan N Patel,Andras J. Bauer,Alexandra M. Cantley,Wan Seok Yang,Barclay Morrison,Brent R. Stockwell,Brent R. Stockwell +12 more
TL;DR: This paper identified the small molecule ferrostatin-1 as a potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices, suggesting similarities between these two processes.
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Apoptosis in the pathogenesis and treatment of disease
TL;DR: In multicellular organisms, homeostasis is maintained through a balance between cell proliferation and cell death, and recent evidence suggests that alterations in cell survival contribute to the pathogenesis of a number of human diseases.
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Regulation of Ferroptotic Cancer Cell Death by GPX4
Wan Seok Yang,Rohitha SriRamaratnam,Matthew Welsch,Kenichi Shimada,Rachid Skouta,Vasanthi S. Viswanathan,Vasanthi S. Viswanathan,Jaime H. Cheah,Paul A. Clemons,Alykhan F. Shamji,Clary B. Clish,Lewis M. Brown,Albert W. Girotti,Virginia W. Cornish,Stuart L. Schreiber,Brent R. Stockwell +15 more
TL;DR: Targeted metabolomic profiling and chemoproteomics revealed that GPX4 is an essential regulator of ferroptotic cancer cell death and sensitivity profiling in 177 cancer cell lines revealed that diffuse large B cell lymphomas and renal cell carcinomas are particularly susceptible to GPx4-regulated ferroPTosis.
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Cell Death: Critical Control Points
TL;DR: The identification of critical control points in the cell death pathway has yielded fundamental insights for basic biology, as well as provided rational targets for new therapeutics.
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