Glutaminolysis and Transferrin Regulate Ferroptosis.

TL;DR: The results demonstrate the synergistic effect of sorafenib and sulfasalazine in downregulating BCAT2 expression and dictating ferroptotic death, whereBCAT2 can also be used to predict the responsiveness of cancer cells to ferroPTosis-inducing therapies.

TL;DR: Based on the mRNA expression information from The Cancer Genome Atlas, Wang et al. as discussed by the authors compared tumor and normal tissues in terms of the gene expression, for identifying differentially expressed genes (DEGs).

TL;DR: The mechanism of ferroptosis and its association with RA pathogenesis is focused on, and the status of therapeutics targeting ferroPTosis in the treatment of patients with RA is discussed.

TL;DR: This review discusses ferroPTosis-related metabolisms, important molecules directly or indirectly targeting iron metabolism and lipid peroxidation, and transcriptional regulation of ferroptosis, revealing the role of feroptosis in the progression of stroke.

TL;DR: This paper identified the small molecule ferrostatin-1 as a potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices, suggesting similarities between these two processes.

TL;DR: In multicellular organisms, homeostasis is maintained through a balance between cell proliferation and cell death, and recent evidence suggests that alterations in cell survival contribute to the pathogenesis of a number of human diseases.

TL;DR: Targeted metabolomic profiling and chemoproteomics revealed that GPX4 is an essential regulator of ferroptotic cancer cell death and sensitivity profiling in 177 cancer cell lines revealed that diffuse large B cell lymphomas and renal cell carcinomas are particularly susceptible to GPx4-regulated ferroPTosis.

TL;DR: The identification of critical control points in the cell death pathway has yielded fundamental insights for basic biology, as well as provided rational targets for new therapeutics.