Glucocorticoids Decrease Thyrotropin-Releasing Hormone Messenger Ribonucleic Acid Expression in the Paraventricular Nucleus of the Human Hypothalamus
TL;DR: In this paper, the authors measured TRH mRNA expression in human hypothalami obtained at autopsy by means of quantitative trH mRNA in situ hybridization and found that in corticosteroid-treated subjects (n = 10), the TRH hybridization signal was decreased as compared with matched control subjects (N = 10) (Mann-Whitney U test, P = 0.02).
read more
Abstract: The way glucocorticoids affect TRH mRNA expression in the paraventricular nucleus of the hypothalamus is still unclear. In view of its relevance for Cushing's syndrome and depression, we measured TRH mRNA expression in human hypothalami obtained at autopsy by means of quantitative TRH mRNA in situ hybridization. In corticosteroid-treated subjects (n = 10), TRH mRNA hybridization signal was decreased as compared with matched control subjects (n = 10) (Mann-Whitney U test, P = 0.02). By inference, hypercortisolism as present in patients with Cushing's syndrome or major depression may contribute to lower serum TSH or symptoms of depression by lowering hypothalamic TRH expression.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
The thyroid-brain interaction in thyroid disorders and mood disorders.
TL;DR: This work reviews the relationship between thyroid hormone and neuropsychiatric symptoms in patients with primary thyroid disease and primary mood disorders and investigates the role of thyroid hormone in the adult brain.
418
Drugs that suppress TSH or cause central hypothyroidism.
TL;DR: Mechanisms governing TSH suppression of these drugs and the clinical relevance of these effects are explored.
250
Thyrotropin secretion patterns in health and disease
TL;DR: This review examines the hypothalamo-pituitary-thyroid axis particularly in relation to the regulated 24-hour serum TSH concentration profiles in physiological and pathophysiological conditions, including obesity, primary hypothyroidism, pituitary diseases, psychiatric disorders, and selected neurological diseases.
Changes in pituitary function with ageing and implications for patient care.
TL;DR: The mechanisms mediating clinical facets of changes in the hypothalamic–pituitary axis during ageing are critically discussed, and the extent to which confounding factors operate to obscure ageing-related effects is critically discussed.
Potential interaction between SARS-CoV-2 and thyroid: a review.
TL;DR: In this article, the potential interaction between severe acute respiratory syndrome coronavirus 2 and the thyroid is poorly understood, and limited available evidence indicates there is no pathological evidence of thyroid injury caused by SARS-CoV-2.
References
Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus.
Gábor Légrádi,Charles H. Emerson,Rexford S. Ahima,Jeffrey S. Flier,Ronald M. Lechan,Ronald M. Lechan +5 more
TL;DR: Fasted animals showed significant reduction in plasma total and free T4 and T3 levels compared with controls, that were restored toward normal by the administration of leptin, and the possibility that leptin may have an important role in the neuroendocrine regulation of the thyroid axis was raised.
482
Daily cortisol production rate in man determined by stable isotope dilution/mass spectrometry.
Nora V. Esteban,Therese Loughlin,Alfred L. Yergey,Joanna K Zawadzki,J. D. Booth,Jorg C. Winterer,D. Lynn Loriaux +6 more
TL;DR: It is suggested that the FPR in normal subjects may be lower than previously believed and patients with Cushing's syndrome demonstrated unequivocal elevation of FPR and cortisol concentration correlated during each sample period in normal volunteers, indicating that cortisol secretion, rather than metabolism, is mainly responsible for changes in plasma cortisol.
474
The Longitudinal Course of Psychopathology in Cushing’s Syndrome after Correction of Hypercortisolism
Lorah D. Dorn,Ellen S. Burgess,Theodore C. Friedman,Billinda Dubbert,Philip W. Gold,George P. Chrousos +5 more
TL;DR: It is concluded that CS is associated with AD symptomatology, which gradually improves with time after correction of hypercortisolism, which may be due to glucocorticoid-induced suppression of hypothalamic CRH secretion.
239
Complex alteration of thyroid function in healthy centenarians
Stefano Mariotti,Giuseppe Barbesino,Patrizio Caturegli,Luigi Bartalena,Paolo Sansoni,Francesco Fagnoni,Daniela Monti,Umberto Fagiolo,Claudio Franceschi,Aldo Pinchera +9 more
TL;DR: Thyroid function appears to be well preserved until the eighth decade of life if healthy subjects are studied, whereas a reduction of serum FT3 is observed in extreme aging.
233
Corticotropin Releasing Hormone in the Pathophysiology of Melancholic and Atypical Depression and in the Mechanism of Action of Antidepressant Drugs
TL;DR: The data suggest that hypercortisolism is not the only form of HPA dysregulation in major depression, and raise the question that the hyperphagia, hypersomnia, and fatigue associated with syndromes of atypical depression could reflect a central deficiency of a potent arousal-producing anorexogenic neuropeptide.
214