Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation

TL;DR: This study reviews the development status of creatine sports nutrition supplements, exploring its mechanisms, effects on athletic performance, safety, and usage guidelines for high-level athletes, with a focus on China's future development direction.

TL;DR: In older adults, concurrent creatine supplementation and resistance training increase lean body mass, enhance fatigue resistance, increase muscle strength, and improve performance of activities of daily living to a greater extent than resistance training alone.

TL;DR: The brain creatine (Cr) system plays a crucial role in maintaining bioenergetic flux and is disrupted in AD, and the potential for Cr supplementation as a treatment for AD is discussed.

TL;DR: Competition with 5g of creatine monohydrate, four or six times a day for 2 or more days resulted in a significant increase in the total creatine content of the quadriceps femoris muscle measured in 17 subjects, and in some the increase was as much as 50%.

TL;DR: A rapid way to "creatine load" human skeletal muscle is to ingest 20 g of creatine for 6 days, which can be maintained by ingestion of 2 g/day thereafter, and the ingestion of 3 g creatine/day is in the long term likely to be as effective at raising tissue levels as this higher dose.

TL;DR: It was found that oral administration of creatine produced a dose-dependent improvement in motor performance and extended survival in G93A transgenic mice, and it protected mice from loss of both motor neurons and substantia nigra neurons at 120 days of age.

TL;DR: Investigation of the influence of oral creatine supplementation on skeletal muscle isokinetic torque and the accumulation of plasma ammonia and blood lactate during five bouts of maximal exercise found muscle peak torque production was greater and plasma ammonia accumulation was lower during and after exercise after creatine ingestion.