Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation

TL;DR: S1P as a growth mediator may play an important role in skeletal muscle adaptations following resistance training and there were significant correlations between plasma S1P and gene expression of S 1P2, 3 receptors with geneexpression of MyoD.

TL;DR: In this paper, a revisao tem como objetivo sintetizar os principais estudos desenvolvidos sobre o topic and destacar as perspectivas desse promissor campo de pesquisa e intervencao.

TL;DR: In this paper, the authors examined the effect of Cr supplementation (Cr+; 14 days @ 300mg/kg) on skeletal muscle damage following 15 and 25 LCLs.

TL;DR: Competition with 5g of creatine monohydrate, four or six times a day for 2 or more days resulted in a significant increase in the total creatine content of the quadriceps femoris muscle measured in 17 subjects, and in some the increase was as much as 50%.

TL;DR: A rapid way to "creatine load" human skeletal muscle is to ingest 20 g of creatine for 6 days, which can be maintained by ingestion of 2 g/day thereafter, and the ingestion of 3 g creatine/day is in the long term likely to be as effective at raising tissue levels as this higher dose.

TL;DR: It was found that oral administration of creatine produced a dose-dependent improvement in motor performance and extended survival in G93A transgenic mice, and it protected mice from loss of both motor neurons and substantia nigra neurons at 120 days of age.

TL;DR: Investigation of the influence of oral creatine supplementation on skeletal muscle isokinetic torque and the accumulation of plasma ammonia and blood lactate during five bouts of maximal exercise found muscle peak torque production was greater and plasma ammonia accumulation was lower during and after exercise after creatine ingestion.