Glial connexin expression and function in the context of Alzheimer's disease.
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TL;DR: Recent data that suggest glial Cx channels participate in the neurodegenerative process of Alzheimer's disease are summarized and discussed.
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About: This article is published in Biochimica et Biophysica Acta. The article was published on 01 Aug 2012. and is currently open access. The article focuses on the topics: Gliosis & Neuroglia.
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Citations
Neuroscience forefront review hemichannels: new pathways for gliotransmitter release
T. D. Montero,J. A. Orellana +1 more
- 01 Jan 2015
TL;DR: The current knowledge on the hemichan- nel-dependent release of gliotransmitters in the physiology and pathophysiology of the CNS is reviewed.
Connexins in the Central Nervous System: Physiological Traits and Neuroprotective Targets.
Nunzio Vicario,Agata Zappalà,Giovanna Calabrese,Rosario Gulino,Carmela Parenti,Massimo Gulisano,Rosalba Parenti +6 more
TL;DR: The contribution of connexins in neural cells populations during neurodegenerative processes is pointed out to explore potential neuroprotective therapeutic applications and the controversial role of these proteins and their mediated interactions during neuroprotection is discussed.
A Review of Gap Junction Protein and its Potential Role in Nervous System-Related Disease.
Qiong Xiang,Xiao-Lin Liu,Jia-Jia Chen,Liang Yang,Li-Ni Liu,Jing Deng,J. Tao,Xian-Hui Li +7 more
TL;DR: The possible mechanism of its action in nervous system-related diseases and treatment are reviewed and its function of regulating immune response, cell proliferation, migration, apoptosis, and carcinogenesis is reviewed.
Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1
TL;DR: Current insights and emerging concepts, particularly the impact of connexin43 and pannexin1, under neuroprotective and neurodegenerative conditions within the context of astrocytes are focused on.
Gap junctions and hemichannels composed of connexins: potential therapeutic targets for neurodegenerative diseases
Hideyuki Takeuchi,Akio Suzumura +1 more
TL;DR: This work found that abnormally activated microglia secrete glutamate via gap-junction hemichannels on the cell surface and significantly suppressed excessive microglial glutamate release and improved disease symptoms in animal models of neurologic conditions such as stroke, multiple sclerosis, amyotrophic lateral sclerosis, and Alzheimer's disease.
References
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TL;DR: Evidence that the presenilin proteins, mutations in which cause the most aggressive form of inherited AD, lead to altered intramembranous cleavage of the beta-amyloid precursor protein by the protease called gamma-secretase has spurred progress toward novel therapeutics and provided discrete biochemical targets for drug screening and development.
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Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TL;DR: By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.
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TL;DR: Extracellular ATP regulates microglial branch dynamics in the intact brain, and its release from the damaged tissue and surrounding astrocytes mediates a rapid microglia response towards injury.
Molecular dissection of reactive astrogliosis and glial scar formation.
TL;DR: Developments in the signaling mechanisms that regulate specific aspects of reactive astrogliosis are reviewed and the potential to identify novel therapeutic molecular targets for diverse neurological disorders is highlighted.
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Glial and neuronal control of brain blood flow.
David Attwell,Alastair M. Buchan,Serge Charpak,Martin Lauritzen,Brian A. MacVicar,Eric A. Newman +5 more
TL;DR: It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation, and that blood flow may be controlled by capillaries as well as by arterioles.