Glial connexin expression and function in the context of Alzheimer's disease.
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TL;DR: Recent data that suggest glial Cx channels participate in the neurodegenerative process of Alzheimer's disease are summarized and discussed.
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About: This article is published in Biochimica et Biophysica Acta. The article was published on 01 Aug 2012. and is currently open access. The article focuses on the topics: Gliosis & Neuroglia.
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TL;DR: Extracellular ATP regulates microglial branch dynamics in the intact brain, and its release from the damaged tissue and surrounding astrocytes mediates a rapid microglia response towards injury.
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TL;DR: Developments in the signaling mechanisms that regulate specific aspects of reactive astrogliosis are reviewed and the potential to identify novel therapeutic molecular targets for diverse neurological disorders is highlighted.
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Glial and neuronal control of brain blood flow.
David Attwell,Alastair M. Buchan,Serge Charpak,Martin Lauritzen,Brian A. MacVicar,Eric A. Newman +5 more
TL;DR: It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation, and that blood flow may be controlled by capillaries as well as by arterioles.