Get a grip: individual variations in grip strength are a marker of brain health

TL;DR: The results suggest that perceptual decisions are mediated by oscillatory interactions within overlapping local and large-scale cortical networks.

TL;DR: Stand-alone handgrip strength should be considered an umbrella assessment of the body systems that contribute to strength capacity, and a panoptic measurement of muscle strength that is representative of overall health status, not a specific health condition.

TL;DR: Handgrip strength could be used for assessing cognitive status in aging Americans and strength capacity should be monitored in those with cognitive impairment, as strength capacity and cognitive function may parallel each other.

TL;DR: Findings over the past 15 years have demonstrated that changes in grip and leg extensor strength are not primarily due to muscle atrophy per se, and that to a large extent, are reflective of declines in the integrity of the nervous system.

TL;DR: Sarcopenia is now clinically defined as a loss of muscle mass coupled with functional deterioration (either walking speed or distance or grip strength) and there is now a valid simple questionnaire to screen for sarcopenia, i.e., the SARC-F.

TL;DR: The relationship between task complexity and degree of age-related changes suggests that results from simple, laboratory-based tasks may only partially explain impairments observed during the performance of activities of daily living, since the latter ones are typically more complex.

TL;DR: Handgrip strength training of the free limb attenuated strength loss during unilateral immobilization, and the maintenance of strength in the immobilized limb via the cross-education effect may be associated with increased motor cortex activation.

TL;DR: Sarcopenia illustrates the impact that constantly advancing medical knowledge has on disease definition and taxonomy and shows how a lack of clarity or consensus in a medical definition can affect drug innovation: in particular, how such a lack can influence academic research, drug development, and regulatory expectations.