Genomic resolution of an aggressive, widespread, diverse and expanding meningococcal serogroup B, C and W lineage
Jay Lucidarme,Dorothea M. C. Hill,Holly B. Bratcher,Steve J. Gray,Mignon du Plessis,Raymond S. W. Tsang,Julio A. Vázquez,Muhamed-Kheir Taha,Mehmet Ceyhan,Adriana M. Efron,Maria Cecília Gorla,Jamie Findlow,Keith A. Jolley,Martin C. J. Maiden,Ray Borrow +14 more
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TL;DR: High resolution ‘genomic’ multilocus sequence typing is necessary to resolve and monitor the spread of diverse cc11 lineages globally.
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About: This article is published in Journal of Infection. The article was published on 01 Nov 2015. and is currently open access. The article focuses on the topics: Multilocus sequence typing.
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The Global Meningococcal Initiative meeting on prevention of meningococcal disease worldwide: epidemiology, surveillance, hypervirulent strains, antibiotic resistance and high-risk populations
Reinaldo Acevedo,Xilian Bai,Ray Borrow,Dominique A. Caugant,Josefina Carlos,Mehmet Ceyhan,Hannah Christensen,Yanet Climent,Philippe De Wals,Ener Cagri Dinleyici,Gabriela Echániz-Aviles,Ahmed Hakawi,Hajime Kamiya,Andromachi Karachaliou,Jay Lucidarme,Susan Meiring,Konstantin Mironov,Marco Aurélio Palazzi Sáfadi,Zhujun Shao,Vinny Smith,Robert Steffen,Bianca Stenmark,Muhamed-Kheir Taha,Caroline Trotter,Julio A. Vázquez,Bingqing Zhu +25 more
TL;DR: There was, however, evidence that reduced susceptibility to antibiotics was increasing worldwide, and several other global initiatives underway to support IMD protection and prevention were reinforced.
An international invasive meningococcal disease outbreak due to a novel and rapidly expanding serogroup W strain, Scotland and Sweden, July to August 2015
Jay Lucidarme,Kevin J. Scott,Roisin Ure,Andrew Smith,Andrew Smith,Diane S. J. Lindsay,Bianca Stenmark,Susanne Jacobsson,Hans Fredlund,J. C. Cameron,Alison Smith-Palmer,Jim McMenamin,Steve J. Gray,Helen Campbell,Shamez N Ladhani,Jamie Findlow,Paula Mölling,Ray Borrow +17 more
TL;DR: High-resolution genomic typing schemes are used to confirm that the Jamboree-associated cases constituted a genuine outbreak and that this was due to a novel and rapidly expanding strain descended from the strain that has recently expanded in South America and the United Kingdom.
Recent changes in the epidemiology of Neisseria meningitidis serogroup W across the world, current vaccination policy choices and possible future strategies.
TL;DR: Global trends in MenW-IMD epidemiology over the last 5–10 years are described, with emphasis on the response of national/regional health authorities to increased MenW prevalence in impacted areas.
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References
Multilocus sequence typing: A portable approach to the identification of clones within populations of pathogenic microorganisms
Martin C. J. Maiden,Jane A. Bygraves,Edward J. Feil,Giovanna Morelli,Joanne E. Russell,Rachel Urwin,Qing Zhang,Jiaji Zhou,Kerstin Zurth,Dominique A. Caugant,Ian M. Feavers,Mark Achtman,Brian G. Spratt +12 more
TL;DR: Multilocus sequence typing (MLST), which exploits the unambiguous nature and electronic portability of nucleotide sequence data for the characterization of microorganisms, can be applied to almost all bacterial species and other haploid organisms, including those that are difficult to cultivate.
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BIGSdb: Scalable analysis of bacterial genome variation at the population level
TL;DR: The Bacterial Isolate Genome Sequence Database (BIGSDB) represents a freely available resource that will assist the broader community in the elucidation of the structure and function of bacteria by means of a population genomics approach.
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TL;DR: SplitsTree is an interactive program, for analyzing and visualizing evolutionary data, that implements the method of split decomposition, and supports a number of distances transformations, the computation of parsimony splits, spectral analysis and bootstrapping.
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Scott A. Halperin,Julie A. Bettinger,Brian Greenwood,Lee H. Harrison,Jane Jelfs,Shamez N Ladhani,Peter McIntyre,Mary Ramsay,Marco Aurélio Palazzi Sáfadi +8 more
TL;DR: The imminent availability of recombinant broadly protective serogroups B vaccines may provide the tools for further control of invasive meningococcal disease in areas where serogroup B disease predominates.
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Effect of a quadrivalent meningococcal ACWY glycoconjugate or a serogroup B meningococcal vaccine on meningococcal carriage: an observer-blind, phase 3 randomised clinical trial
Robert C. Read,David Baxter,David Chadwick,Saul N. Faust,Saul N. Faust,Adam Finn,Stephen B. Gordon,Paul T. Heath,David J. M. Lewis,Andrew J. Pollard,David P. J. Turner,Rohit Bazaz,Amitava Ganguli,Tom Havelock,Tom Havelock,Keith R. Neal,Ifeanyichukwu O Okike,Begonia Morales-Aza,Kamlesh Patel,Matthew D. Snape,John Williams,Stefanie Gilchrist,Steve J. Gray,Martin C. J. Maiden,Daniela Toneatto,Huajun Wang,Maggie McCarthy,Peter M. Dull,Ray Borrow,Ray Borrow +29 more
TL;DR: Although there was no significant difference between groups at 1 month after vaccine course, MenACWY-CRM and 4CMenB vaccines reduced meningococcal carriage rates during 12 months after vaccination and therefore might affect transmission when widely implemented.
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