Journal Article10.1016/J.BONE.2014.09.025
Genome-wide pathway-based association study implicates complement system in the development of Kashin-Beck disease in Han Chinese
Feng Zhang,Yan Wen,Xiong Guo,Yin-gang Zhang,Sen Wang,Tie-Lin Yang,Hui Shen,Xiang-Ding Chen,Li-Jun Tan,Qing Tian,Hong-Wen Deng +10 more
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TL;DR: This study is the first to suggest that complement system-related CACC pathway contributed to the development of KBD.
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About: This article is published in Bone. The article was published on 01 Feb 2015. The article focuses on the topics: Kashin–Beck disease.
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Citations
Complement involvement in bone homeostasis and bone disorders
TL;DR: The present review summarises the current view on the role of the complement cascade on bone, both under homeostatic physiological conditions and under inflammatory and infectious conditions, which strongly affect the bone and skeletal health.
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Network pharmacology and experimental validation-based approach to understand the effect and mechanism of Taohong Siwu Decoction against ischemic stroke.
Lingyu Pan,Can Peng,Lei Wang,Lili Li,Shih Shien Huang,Chan Kok Fei,Ni Wang,Furui Chu,Daiyin Peng,Xianchun Duan +9 more
TL;DR: Wang et al. as mentioned in this paper identified the intersection between the components and targets, constructed a protein-protein interaction (PPI) network, carried out GO and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, and verified the results of network pharmacology were verified by in vivo experiments.
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The anaphylatoxin C5a: Structure, function, signaling, physiology, disease, and therapeutics.
Manaswini Ghosh,Soumendra Rana +1 more
TL;DR: A comprehensive overview of human C5a in the context of its structure and signaling under several pathophysiological conditions, including the current and future therapeutic applications targeting C5A, is provided in this article .
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Integrative analysis of proteomics and metabolomics of anaphylactoid reaction induced by Xuesaitong injection
TL;DR: Results disclosed that 13 differential proteins and 28 metabolites, which were further approved using the ELISA method and reference standards, respectively, were suggested as potential biomarkers to examine the anaphylactoid mechanism.
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Identification of core genes and prediction of miRNAs associated with osteoporosis using a bioinformatics approach
TL;DR: Results indicate potential biomarkers in the pathogenesis of OP and therapeutic targets, and enriched GO terms and pathways, including 'nervous system development', 'regulation of molecular function', 'glutamatergic synapse pathway' and 'pathways in cancer'.
References
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Principal components analysis corrects for stratification in genome-wide association studies
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TL;DR: This work describes a method that enables explicit detection and correction of population stratification on a genome-wide scale and uses principal components analysis to explicitly model ancestry differences between cases and controls.
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Common genetic variants on 5p14.1 associate with autism spectrum disorders
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TL;DR: The results implicate neuronal cell-adhesion molecules in the pathogenesis of ASDs, and represent, to the authors' knowledge, the first demonstration of genome-wide significant association of common variants with susceptibility to ASDs.
Pathway-Based Approaches for Analysis of Genomewide Association Studies
Kai Wang,Mingyao Li,Maja Bucan +2 more
TL;DR: It is demonstrated that pathway-based approaches, which jointly consider multiple contributing factors in the same pathway, might complement the most-significant SNPs/genes approach and provide additional insights into interpretation of GWA data on complex diseases.
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