Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates
Gregory Hannum,Justin Guinney,Ling Zhao,Ling Zhao,Li Zhang,Guy Hughes,Srinivas R. Sadda,Brandy Klotzle,Marina Bibikova,Jian-Bing Fan,Yuan Gao,Rob Deconde,Menzies Chen,Indika Rajapakse,Stephen H. Friend,Trey Ideker,Kang Zhang,Kang Zhang +17 more
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TL;DR: A quantitative model of aging is built using measurements at more than 450,000 CpG markers from the whole blood of 656 human individuals, aged 19 to 101, to measure the rate at which an individual's methylome ages, which is impacted by gender and genetic variants.
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About: This article is published in Molecular Cell. The article was published on 24 Jan 2013. and is currently open access. The article focuses on the topics: Biomarkers of aging & Geroscience.
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Clonal Hematopoiesis and Its Impact on Human Health.
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Association of Adverse Childhood Experiences With Accelerated Epigenetic Aging in Midlife
Kyeezu Kim,Kristine Yaffe,David H. Rehkopf,Yinan Zheng,Drew R. Nannini,Amanda M. Perak,Jason M. Nagata,Gregory E. Miller,Kai Zhang,Donald M. Lloyd-Jones,Brian T. Joyce,Lifang Hou +11 more
TL;DR: In this article , the association of adverse childhood experiences with five DNA methylation-based measures of accelerated epigenetic aging at 15 to 20 years of follow-up was investigated, and it was shown that adverse experiences were associated with increased epigenetic age.
Postmortem age estimation via DNA methylation analysis in buccal swabs from corpses in different stages of decomposition—a “proof of principle” study
Barbara Elisabeth Koop,Felix Mayer,Tanju Gündüz,Jacqueline Blum,Julia Becker,Judith Schaffrath,Wolfgang Wagner,Yang Han,Petra Boehme,Stefanie Ritz-Timme +9 more
TL;DR: Buccal swabs are a suitable and easy to collect source for DNA methylation analysis as long as sufficient amounts of DNA are present.
References
Controlling the false discovery rate: a practical and powerful approach to multiple testing
Yoav Benjamini,Yosef Hochberg +1 more
TL;DR: In this paper, a different approach to problems of multiple significance testing is presented, which calls for controlling the expected proportion of falsely rejected hypotheses -the false discovery rate, which is equivalent to the FWER when all hypotheses are true but is smaller otherwise.
Regularization and variable selection via the elastic net
Hui Zou,Trevor Hastie +1 more
TL;DR: It is shown that the elastic net often outperforms the lasso, while enjoying a similar sparsity of representation, and an algorithm called LARS‐EN is proposed for computing elastic net regularization paths efficiently, much like algorithm LARS does for the lamba.
Regularization Paths for Generalized Linear Models via Coordinate Descent
TL;DR: In comparative timings, the new algorithms are considerably faster than competing methods and can handle large problems and can also deal efficiently with sparse features.
Bioconductor: open software development for computational biology and bioinformatics
Robert Gentleman,Vincent J. Carey,Douglas M. Bates,Benjamin M. Bolstad,Marcel Dettling,Sandrine Dudoit,Byron Ellis,Laurent Gautier,Yongchao Ge,Jeff Gentry,Kurt Hornik,Torsten Hothorn,Wolfgang Huber,Stefano Maria Iacus,Rafael A. Irizarry,Friedrich Leisch,Cheng Li,Martin Maechler,A. J. Rossini,Günther Sawitzki,Colin A. Smith,Gordon K. Smyth,Luke Tierney,Jean Yang,Jianhua Zhang +24 more
TL;DR: Details of the aims and methods of Bioconductor, the collaborative creation of extensible software for computational biology and bioinformatics, and current challenges are described.
The Mathematical Theory of Communication
TL;DR: The theory of communication is extended to include a number of new factors, in particular the effect of noise in the channel, and the savings possible due to the statistical structure of the original message anddue to the nature of the final destination of the information.
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