Genome-wide association study of behavioral, physiological and gene expression traits in outbred CFW mice.

TL;DR: The objective of this study was to use outbred rats to identify the genetic loci underlying obesity and related morphometric and metabolic traits.

TL;DR: In this paper, the authors sequenced the genomes of 2,101 emm28 S. pyogenes invasive strains, from which they selected 492 phylogenetically diverse strains for transcriptome analysis and 50 strains for virulence assessment.

TL;DR: Pan-genomics can encompass most of the genetic diversity of a species or population and has proved to be a powerful tool for studying genomic evolution and the origin and domestication of species, and for providing information for plant improvement as discussed by the authors .

TL;DR: How mouse systems genetics helps to understand human diseases and to advance the development of precision medicine is discussed, with an emphasis on the existing resources and strategies.

TL;DR: As progressively larger numbers of individuals are sequenced, increasingly accurate genotype calls can be generated for a given sequence depth, and low-coverage sequencing is used to build a reference panel that can drive imputation into additional samples to increase power further.

TL;DR: How highthroughput RNA-seq technologies have increased the authors' understanding of the mechanisms that give rise to alternative transcripts and their alternative translation is reviewed.

TL;DR: A high-density mouse genotyping array containing 623,124 single-nucleotide polymorphisms that captures the known genetic variation present in the laboratory mouse opens the door to the characterization of genetic diversity, copy-number variation, allele-specific gene expression and DNA methylation.

TL;DR: It is shown that Fst mutant mice exhibit haploinsufficiency, with muscles of Fst heterozygotes having significantly reduced size, a shift toward more oxidative fiber types, an impairment of muscle remodeling in response to cardiotoxin-induced injury, and a reduction in tetanic force production yet a maintenance of specific force.