Generating samples under a Wright-Fisher neutral model of genetic variation.
TL;DR: A Monte Carlo computer program is available to generate samples drawn from a population evolving according to a Wright-Fisher neutral model, and the samples produced can be used to investigate the sampling properties of any sample statistic under these neutral models.
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Abstract: A Monte Carlo computer program is available to generate samples drawn from a population evolving according to a Wright-Fisher neutral model. The program assumes an infinite-sites model of mutation, and allows recombination, gene conversion, symmetric migration among subpopulations, and a variety of demographic histories. The samples produced can be used to investigate the sampling properties of any sample statistic under these neutral models.
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Citations
Evolutionary genetics of the human Rh blood group system.
George H. Perry,Yali Xue,Richard S. Smith,Wynn K. Meyer,Minal Çalışkan,Omar Yanez-Cuna,Omar Yanez-Cuna,Arthur Lee,Maria Gutierrez-Arcelus,Maria Gutierrez-Arcelus,Carole Ober,Edward J. Hollox,Chris Tyler-Smith,Charles Lee +13 more
TL;DR: This study used new molecular and genomic data generated from four HapMap population samples to test the idea that positive selection for an as-of-yet unknown fitness benefit of the RHD deletion may have offset the otherwise negative fitness effects of hemolytic disease of the newborn, and found no evidence that positive natural selection affected the frequency of theRHD deletion.
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Loss and gain of function in SERPINB11: an example of a gene under selection on standing variation, with implications for host-pathogen interactions.
Susana Seixas,Nevyana Ivanova,Zélia Ferreira,Zélia Ferreira,Jorge Rocha,Jorge Rocha,Bruno L. Victor +6 more
TL;DR: This work represents the first description of a resurrected gene in humans, and may well exemplify selection on standing variation triggered by drastic ecological shifts.
The Empirical Distribution of Singletons for Geographic Samples of DNA Sequences.
TL;DR: The empirical distribution of singletons is a useful measure to analyze results of sequencing projects based on large scale sampling of individuals across geographic space and leads to accurate estimates of the geographic origin of range expansions.
PipeMaster: inferring population divergence and demographic history with approximate Bayesian computation and supervised machine-learning in R
TL;DR: This study demonstrates the utility of the newly developed R-package to simulate summary statistics to perform ABC and SML inferences and finds that SML is more efficient than ABC and a higher accuracy when inferring parameters with SML.
Haplotype inference with pseudo-Boolean optimization
TL;DR: This paper provides a detailed description of RPoly, a PBO approach for the haplotype inference by pure parsimony (HIPP) problem and an extensive evaluation of existent HIPP solvers confirms that RPoly is currently the most efficient and robust HIPP approach.
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References
Numerical recipes in C
William H. Press,Saul A. Teukolsky,William T. Vetterling,Brian P. Flannery +3 more
- 01 Jan 1994
TL;DR: The Diskette v 2.06, 3.5''[1.44M] for IBM PC, PS/2 and compatibles [DOS] Reference Record created on 2004-09-07, modified on 2016-08-08.
Properties of a neutral allele model with intragenic recombination.
TL;DR: An infinite-site neutral allele model with crossing-over possible at any of an infinite number of sites is studied and the effect of intragenic recombination on the homozygosity test of Watterson and on the number of unique alleles in a sample is determined.
886
•Book
Mathematical Population Genetics
Warren J. Ewens
- 01 Jan 1979
TL;DR: In this paper, the authors present a model based on the Wright-Fisher In.nitely Many Alleles Model and the Cannings (Exchangeable) Model: Two-Alleles 3.4.