Open AccessBook
Gene Mapping in Laboratory Mammals Part B
Roy Robinson
- 01 Jan 1972
39
About: The article was published on 01 Jan 1972. and is currently open access. The article focuses on the topics: Gene mapping.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat.
Howard J. Jacob,Howard J. Jacob,Klaus Lindpaintner,Klaus Lindpaintner,Stephen E Lincoln,Kenro Kusumi,Ruth K. Bunker,Yipei Mao,Detlev Ganten,Victor J. Dzau,Eric S. Lander +10 more
TL;DR: Strong genetic evidence is reported that a gene, Bp1, having a major effect on blood pressure maps to rat chromosome 10 with a LOD score of 5.10 and is closely linked to the rat gene encoding angiotensin-converting enzyme (ACE), an enzyme that plays a major role in blood pressure homeostasis and is an important target of anti-hypertensive drugs.
753
The Major Histocompatibility System of the Rat (Ag-B or H-1 System)
E. Günther,O. Štark +1 more
- 01 Jan 1977
TL;DR: The experimental use of the laboratory rat, Rattus norvegicus (Robinson 1965), resembles in general that of the Laboratory mouse, Mus musculus, which belong to different genera in the family of Muridae.
71
Genetics and ontogeny of alcohol dehydrogenase isozymes in the mouse: evidence for a cis-acting regulator gene (Adt-i) controlling C2 isozyme expression in reproductive tissues and close linkage of Adh-3 and Adt-i on chromosome 3.
TL;DR: Ontogenetic analyses demonstrated that ADH-B2 is present throughout development from late fetal stages in stomach, liver, and kidney and no recombinants were observed among 73 progeny or among 13 inbred strains and six Harwell linkage testing stocks of mice, indicating that Adh-3 and Adt-1 are closely linked or identical genes.
55
Genetics, ontogeny, and testosterone inducibility of aldehyde oxidase isozymes in the mouse: evidence for two genetic loci (aox-1 and aox-2) closely linked on chromosome 1.
TL;DR: Ontogenetic analyses demonstrated that liver Aox-1 appeared just before birth and increased in activity during postnatal development, whereas liver AOX-2 was observed only during post newborn development.
47
Lens opacity: a new gene for congenital cataract on chromosome 10 of the mouse.
TL;DR: A new gene causing congenital cataract in the mouse is reported, which may be useful in the understanding of cataracts in man.
43
References
Leukocyte Culture and Chromosome Preparations from Adult Dog Blood
TL;DR: Plasma is obtained from dog blood after 3 hr settling in a syringe and the fixative, consisting of 45% glacial acetic acid allowed to act for 0.5 hr, was very satisfactory.
8
A description of rho. A non-h-2 isoantigen in rfm mice.
TL;DR: Serological analysis revealed that a locus other than rho was responsible for the moderately strong histocompatibility response, and the antibody formed against rho is a leukoagglutinin and cytotoxin as well as a hemagglUTinin.
8
On the Inheritance of Albinism and Brown Pigmentation in Mice
Horace W. Feldman,Gregory Pincus +1 more
TL;DR: It would seem at the present time premature to speculate regarding the mechanism by which the spindle fiber might operate, in thus making the chromatin specially susceptible to variation in crossing over as a result of X-rays, and, presumably of heat, age and other non-genetic factors.
7