Gas chromatographic-mass spectrometric study of volatile organic metabolites in urines of patients with diabetes mellitus.

TL;DR: In this article, the authors review methodological approaches commonly employed for the determination of human-bodyodor (BO) components and highlight the potential for odor components as a health-diagnosis tool.

TL;DR: A review of headspace gas chromatographic (HS-GC) methods used in the determination of volatile substances in body fluids and tissues from the viewpoints of the design of HS-GC instrumentation, partition coefficients and matrix effects of biological samples, additives to the liquid phase and stabilities of volatile substance in biological samples is presented in this paper.

TL;DR: The high practicability of the multipurpose sampler for both gaseous and liquid samples together with the here shown good reproducibility and sensitivity make this single CIS-GC-MS system very attractive for routine clinical use in metabolic profiling of organic volatile (headspace) and non-volatiles (liquid).

TL;DR: A comparative analysis of unfrozen and frozen-thawed urine showed that samples retained the same number of compounds although variations in the peak areas for some compounds were observed.

TL;DR: Volatile constituents of 30 urines from 10 adults have been studied by gas chromatography, and two also by mass spectrometry, finding that dietary changes have a relatively small effect on the profile of the volatiles, and interindividual patterns are very similar.

TL;DR: Forty-two compounds were identified by gas chromatography—mass spectroscopy, using a modified head-space collection technique, and placed on a chromatogram from a disease diagnosis instrument.

TL;DR: Trace volatile constituents of human urine, serum, and cerebrospinal fluid were concentrated on a porous polymer precolumn, and resolved with high-efficiency glass capillary columns to facilitate effective resolution of underivatized compounds within the volatility range up to docosane.