Journal Article10.1016/0006-8993(90)90290-R
Galanin-induced prolactin release in rats: pharmacological evidence for the involvement of α-adrenergic and opioidergic mechanisms
Hiroyuki Koshiyama,Akira Shimatsu,Yuzuru Kato,Hossein Assadian,Naoki Hattori,Yasuhiro Ishikawa,Tsutomu Tanoh,Noboru Yanaihara,Hiroo Imura +8 more
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TL;DR: The mechanism by which galanin (GAL) stimulates prolactin (PRL) secretion was investigated in urethane-anesthetized male rats and suggest that alpha 2-adrenergic and opioidergic mechanisms are involved in PRL release induced by GAL.
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About: This article is published in Brain Research. The article was published on 22 Jan 1990. The article focuses on the topics: Phentolamine & (+)-Naloxone.
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Citations
Prolactin: Structure, Function, and Regulation of Secretion
TL;DR: The purpose of this review is to provide a comprehensive survey of the current understanding of prolactin's function and its regulation and to expose some of the controversies still existing.
Distribution of galanin-1, -2 and -3 receptor messenger RNAs in central and peripheral rat tissues.
S.M. Waters,J.E. Krause +1 more
TL;DR: The observed expression of multiple galanin receptors in several tissues including hypothalamus, anterior pituitary and spinal cord supports earlier pharmacological studies suggesting the presence of more than one receptor subtype in these regions and illustrates the potential complexity of Galanin-associated actions in rat central nervous system and periphery.
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Three-dimensional representation of the neurotransmitter systems of the human hypothalamus: inputs of the gonadotrophin hormone-releasing hormone neuronal system.
TL;DR: Three dimensional stereoscopic images of GnRH‐immunoreactive (IR) and some peptidergic (neuropeptide Y‐, substance P‐, β‐endorphin‐, leu‐enkaphalin‐, corticotrophin hormone‐releasing‐ and galanin‐ir) and catecholaminergic neurones are provided and the communication of these potential oestrogen‐sensitive neuronal systems with GnRH neurones in the human
89
Centrally administered galanin inhibits osmotically stimulated arginine vasopressin release in conscious rats
TL;DR: The results suggest that central galanin inhibits osmotically stimulated AVP release and endogenous opioids are, at least in part, involved in the mechanism.
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Morphological Evidence for a Galanin‐Opiate Interaction in the Rat Mediobasal Hypothalamus
TL;DR: The present study was designed to elucidate the morphological component underlying these responses in the hypothalamus of colchicine‐pretreated female rats and revealed that deafferentation of the arcuate nucleus did not decrease the density of galanin immunoreactive profiles on the isolated side of the Arcuate nucleus compared to the control side, thus, indicating that the galan in boutons contacting β‐endorphin cells are most probably of local origin.
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References
Galanin — a novel biologically active peptide from porcine intestine
TL;DR: It was found that galanin consists of 29 amino acids and the complete amino acid sequence is: contract smooth muscle preparations from the rat and to cause a mild and sustained hyperglycemia in dog.
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Distribution of galanin immunoreactivity in the central nervous system and the responses of galanin-containing neuronal pathways to injury.
J.L.C. Ch'ng,Nicos D. Christofides,Praveen Anand,S.J. Gibson,Y.S. Allen,H.C. Su,Kazuhiko Tatemoto,J.F.B. Morrison,J.M. Polak,S.R. Bloom +9 more
TL;DR: The decrease of galanin-like immunoreactivity in the dorsal horn of the spinal cord, following dorsal rhizotomy and pre-treatment of rats with capsaicin, indicates that many of the fibres, which are of small diameter, may well be derived from spinal sensory neurones.
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Isolation and characterization of a complementary DNA (galanin) clone from estrogen-induced pituitary tumor messenger RNA.
TL;DR: Results provide the first evidence of a physiological regulator (estrogen) of the expression of the galanin gene and imply that Galanin is secreted by prolactin-secreting tumors.
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Tissue-specific expression of the rat galanin gene
TL;DR: Rat galanin mRNA is located predominantly in the central nervous system and gastrointestinal tract and includes a 17-amino acid region that is nearly identical to the porcine counterpart.
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Morphine- and opioid peptide-induced inhibition of the release of dopamine from tuberoinfundibular neurons
G.A. Gudelsky,John C. Porter +1 more
TL;DR: Results are supportive of the hypothesis that endogenous opioid peptides modulate the release of dopamine by tuberoinfundibular neurons into hypophysial portal blood.
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