Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment

TL;DR: Whether this emerging field of research is a 'mirage' without a clear picture, or truly represents a paradigm shift for cancer research, is posed.

TL;DR: In this article, the alpha-bug hypothesis was proposed that oncogenic bacteria such as enterotoxigenic Bacteroides fragilis (ETBF) induce the development of colorectal cancer through direct interactions with colonic epithelial cells and alterations of microbiota composition.

TL;DR: The miRNA:mRNA interaction network suggested that the upregulation of miR-34a in CRC proceeds via a TLR2/TLR4-dependent response to F. nucleatum, a risk factor for CRC by increasing the expression of inflammatory mediators through a possible miRNA-mediated activation of TLR 2/TLr4.

TL;DR: In an era when spatial transcriptomics and single-cell imaging and analysis have become key tools in mammalian cell and tissue biology, many of these techniques are now being applied to the microbiota and have given important insights that span temporal and spatial scales.

TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.

TL;DR: The Human Microbiome Project Consortium reported the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome as discussed by the authors.

TL;DR: Integrative analyses suggest new markers for aggressive colorectal carcinoma and an important role for MYC-directed transcriptional activation and repression.

TL;DR: The origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit are discussed.