Functional STAT3 deficiency compromises the generation of human T follicular helper cells
Cindy S. Ma,Cindy S. Ma,Danielle T. Avery,Anna Chan,Marcel Batten,Marcel Batten,Jacinta Bustamante,Jacinta Bustamante,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Peter D. Arkwright,Alexandra Y. Kreins,Diana Averbuch,Dan Engelhard,Klaus Magdorf,Sara Sebnem Kilic,Yoshiyuki Minegishi,Shigeaki Nonoyama,Martyn A. French,Martyn A. French,Sharon Choo,Joanne Smart,Jane Peake,Melanie Wong,Paul Gray,Matthew C. Cook,Matthew C. Cook,David A. Fulcher,Jean-Laurent Casanova,Jean-Laurent Casanova,Elissa K. Deenick,Elissa K. Deenick,Stuart G. Tangye,Stuart G. Tangye +33 more
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TL;DR: CD4(+) T cells from patients deficient in IL-12Rβ1, TYK2, STAT1, and STAT3 are examined to further explore the pathways involved in human Tfh cell differentiation and suggest that defective T fh cell development and/or function contributes to the humoral defects observed in STAT3-deficient patients.
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About: This article is published in Blood. The article was published on 26 Apr 2012. and is currently open access. The article focuses on the topics: Interleukin 21 & Cytotoxic T cell.
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Citations
Follicular helper T cells may play an important role in the severity of primary Sjögren's syndrome.
TL;DR: Investigating the possible role of follicular helper T (TFH) cells in the pathogenesis of primary Sjögren's syndrome by analyzing immune-competent cells and serological markers with special emphasis on clinical symptoms found increased TFH cell proportions seem to have an important role in disease development.
179
Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer.
Colin Havenar-Daughton,Colin Havenar-Daughton,Diane G. Carnathan,Diane G. Carnathan,Alba Torrents de la Peña,Matthias Pauthner,Matthias Pauthner,Bryan Briney,Bryan Briney,Samantha M. Reiss,Samantha M. Reiss,Jennifer S. Wood,Kirti Kaushik,Kirti Kaushik,Marit J. van Gils,Sandy L. Rosales,Patricia van der Woude,Michela Locci,Michela Locci,Khoa M. Le,Khoa M. Le,Steven W. de Taeye,Devin Sok,Devin Sok,Ata Ur Rasheed Mohammed,Jessica Huang,Sanjeev Gumber,Anapatricia Garcia,Sudhir Pai Kasturi,Sudhir Pai Kasturi,Bali Pulendran,Bali Pulendran,Bali Pulendran,John P. Moore,Rafi Ahmed,Rafi Ahmed,Grégory Seumois,Dennis R. Burton,Dennis R. Burton,Dennis R. Burton,Rogier W. Sanders,Rogier W. Sanders,Guido Silvestri,Guido Silvestri,Guido Silvestri,Shane Crotty,Shane Crotty,Shane Crotty +47 more
TL;DR: This work explored the immunological barriers to HIV nAb responses by combining a suite of techniques, including longitudinal lymph node fine needle aspirates, and found that nAb development best correlated with booster immunization GC B cell magnitude and Tfh characteristics of the Env-specific CD4 T cells.
177
A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity
Vivien Béziat,Vivien Béziat,Juan Li,Jian-Xin Lin,Cindy S. Ma,Cindy S. Ma,Peng Li,Aziz Bousfiha,Isabelle Pellier,Samaneh Zoghi,Samaneh Zoghi,Safa Baris,Sevgi Keles,Paul Gray,Paul Gray,Ning Du,Yi Wang,Yi Wang,Yoann Zerbib,Yoann Zerbib,Romain Lévy,Romain Lévy,Thibaut Leclercq,Thibaut Leclercq,Frédégonde About,Frédégonde About,Ai Ing Lim,Ai Ing Lim,Geetha Rao,Kathryn Payne,Simon J. Pelham,Simon J. Pelham,Danielle T. Avery,Elissa K. Deenick,Elissa K. Deenick,Bethany Pillay,Bethany Pillay,Janet Chou,Janet Chou,Romain Guery,Romain Guery,Aziz Belkadi,Aziz Belkadi,Antoine Guérin,Antoine Guérin,Mélanie Migaud,Mélanie Migaud,Vimel Rattina,Vimel Rattina,Fatima Ailal,Ibtihal Benhsaien,Matthieu Bouaziz,Matthieu Bouaziz,Tanwir Habib,Damien Chaussabel,Nico Marr,Jamel El-Benna,Bodo Grimbacher,Orli Wargon,Jacinta Bustamante,Bertrand Boisson,Bertrand Boisson,Bertrand Boisson,Ingrid Müller-Fleckenstein,Bernhard Fleckenstein,Marie-Olivia Chandesris,Matthias Titeux,Matthias Titeux,Sylvie Fraitag,Marie-Alexandra Alyanakian,Marianne Leruez-Ville,Capucine Picard,Isabelle Meyts,James P. Di Santo,James P. Di Santo,Alain Hovnanian,Alain Hovnanian,Ayper Somer,Ahmet Ozen,Nima Rezaei,Nima Rezaei,Talal A. Chatila,Talal A. Chatila,Laurent Abel,Laurent Abel,Laurent Abel,Warren J. Leonard,Stuart G. Tangye,Stuart G. Tangye,Anne Puel,Anne Puel,Anne Puel,Jean-Laurent Casanova +92 more
TL;DR: Patients with an autosomal recessive form of HIES due to loss-of-function mutations of a previously uncharacterized gene, ZNF341 are described, revealing a Previously unappreciated layer of transcriptional regulation controlling JAK-STAT signaling.
T follicular helper (Tfh) cells in lupus: Activation and involvement in SLE pathogenesis.
TL;DR: The current knowledge regarding the involvement of T follicular helper cells in SLE pathogenesis is summarized, and potential strategies to target Tfh cells and/or molecules as a therapeutic modality of SLE are discussed.
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References
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation.
Robert J. Johnston,Amanda C. Poholek,Daniel DiToro,Isharat Yusuf,Danelle Eto,Burton E. Barnett,Alexander L. Dent,Joe Craft,Shane Crotty,Shane Crotty +9 more
TL;DR: It is found that expression of the transcription factor Bcl6 in CD4+ T cells is both necessary and sufficient for in vivo TFH differentiation and T cell help to B cells in mice, and that Bcl 6 and Blimp-1 play central but opposing roles inTFH differentiation.
Bcl6 Mediates the Development of T Follicular Helper Cells
Roza Nurieva,Yeonseok Chung,Gustavo J. Martinez,Xuexian O. Yang,Shinya Tanaka,Tatyana D. Matskevitch,Yi Hong Wang,Chen Dong +7 more
TL;DR: It is demonstrated that the transcription factor Bcl6 is both necessary and sufficient for TFH differentiation and subsequent B cell–mediated immunity, suggesting that it is a master regulator of this lineage.
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Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production
Dagmar Breitfeld,Lars Ohl,Elisabeth Kremmer,Joachim W. Ellwart,Federica Sallusto,Martin Lipp,Reinhold Förster +6 more
TL;DR: In this article, expression of CXC chemokine receptor 5 (CXCR5) defines a novel subpopulation of B helper T cells localizing to follicles, based on the characteristic localization within secondary lymphoid organs.
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A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R
Christi L. Parham,Madaline Chirica,Jacqueline C. Timans,Elena Vaisberg,Marilyn Travis,Jeanne Cheung,Stefan Pflanz,Rebecca Zhang,Komal Singh,Felix Vega,Wayne To,Janet Wagner,Anne Marie O'Farrell,Terrill K. McClanahan,Sandra Zurawski,Charles H. Hannum,Daniel M. Gorman,Donna Rennick,Robert A. Kastelein,Rene de Waal Malefyt,Kevin W. Moore +20 more
TL;DR: A novel member of the hemopoietin receptor family is identified as a subunit of the receptor for IL-23, “IL-23R,” which pairs with IL-12Rβ1 to confer IL- 23 responsiveness on cells expressing both subunits.
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Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function
Patrick Schaerli,Katharina Willimann,Alois B. Lang,Martin Lipp,Pius Loetscher,Bernhard Moser +5 more
TL;DR: These properties portray CXCR5+ T cells as a distinct memory T cell subset with B cell helper function, designated here as follicular B helper T cells (TFH).
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