Functional STAT3 deficiency compromises the generation of human T follicular helper cells
Cindy S. Ma,Cindy S. Ma,Danielle T. Avery,Anna Chan,Marcel Batten,Marcel Batten,Jacinta Bustamante,Jacinta Bustamante,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Peter D. Arkwright,Alexandra Y. Kreins,Diana Averbuch,Dan Engelhard,Klaus Magdorf,Sara Sebnem Kilic,Yoshiyuki Minegishi,Shigeaki Nonoyama,Martyn A. French,Martyn A. French,Sharon Choo,Joanne Smart,Jane Peake,Melanie Wong,Paul Gray,Matthew C. Cook,Matthew C. Cook,David A. Fulcher,Jean-Laurent Casanova,Jean-Laurent Casanova,Elissa K. Deenick,Elissa K. Deenick,Stuart G. Tangye,Stuart G. Tangye +33 more
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TL;DR: CD4(+) T cells from patients deficient in IL-12Rβ1, TYK2, STAT1, and STAT3 are examined to further explore the pathways involved in human Tfh cell differentiation and suggest that defective T fh cell development and/or function contributes to the humoral defects observed in STAT3-deficient patients.
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About: This article is published in Blood. The article was published on 26 Apr 2012. and is currently open access. The article focuses on the topics: Interleukin 21 & Cytotoxic T cell.
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Citations
Aberrant T Cell Signaling and Subsets in Systemic Lupus Erythematosus.
TL;DR: A better understanding of the molecular defects including signaling events and gene regulation underlying the dysfunctional T cells in SLE is necessary to pave the path for better management, therapy, and perhaps prevention of this complex disease.
Human T follicular helper (Tfh) cells and disease
Cindy S. Ma,Elissa K. Deenick +1 more
TL;DR: Recent studies have identified the circulating counterparts to tissue Tfh cells and with this has come a wealth of knowledge gained from the study of these cells in human disease.
190
Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23
Rubén Martínez-Barricarte,Janet Markle,Cindy S. Ma,Elissa K. Deenick,Noé Ramírez-Alejo,Federico Mele,Daniela Latorre,Seyed Alireza Mahdaviani,Caner Aytekin,Davood Mansouri,Vanessa L. Bryant,Vanessa L. Bryant,Vanessa L. Bryant,Fabienne Jabot-Hanin,Caroline Deswarte,Caroline Deswarte,Alejandro Nieto-Patlán,Laura Surace,Gaspard Kerner,Gaspard Kerner,Yuval Itan,Yuval Itan,Sandra Jovic,Danielle T. Avery,Natalie Wong,Geetha Rao,Etienne Patin,Etienne Patin,Satoshi Okada,Benedetta Bigio,Bertrand Boisson,Bertrand Boisson,Bertrand Boisson,Franck Rapaport,Yoann Seeleuthner,Yoann Seeleuthner,Monika Schmidt,Aydan Ikinciogullari,Figen Dogu,Gönül Tanır,Payam Tabarsi,Mohammed Reza Bloursaz,Julia K. Joseph,Avneet Heer,Xiao-Fei Kong,Mélanie Migaud,Mélanie Migaud,Tomi Lazarov,Frederic Geissmann,Frederic Geissmann,Frederic Geissmann,Bernhard Fleckenstein,Cecilia S. Lindestam Arlehamn,Alessandro Sette,Alessandro Sette,Anne Puel,Anne Puel,Anne Puel,Jean-François Emile,Esther van de Vosse,Lluis Quintana-Murci,Lluis Quintana-Murci,James P. Di Santo,Laurent Abel,Laurent Abel,Laurent Abel,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Jacinta Bustamante,Stuart G. Tangye,Federica Sallusto,Jean-Laurent Casanova +72 more
TL;DR: These experiments of nature show that human IL-12 and IL-23 are both required for optimal IFN-γ–dependent immunity to mycobacteria, both individually and much more so cooperatively.
Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer
Chen Xue,Qi Jason Yao,Xinyu Gu,Qingmiao Shi,Xin Yuan,Qingfei Chu,Zheng-fu Bao,Juan Lu,Lan-Ju Li +8 more
TL;DR: The Janus kinase signal transducer and activator of transcription (JAK-STAT) pathway is an evolutionarily conserved mechanism of transmembrane signal transduction that enables cells to communicate with the exterior environment as discussed by the authors .
Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies
Cindy S. Ma,Cindy S. Ma,Natalie Wong,Geetha Rao,Danielle T. Avery,James Torpy,Thomas Hambridge,Jacinta Bustamante,Satoshi Okada,Jennifer Stoddard,Elissa K. Deenick,Elissa K. Deenick,Simon J. Pelham,Simon J. Pelham,Kathryn Payne,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Anne Puel,Masao Kobayashi,Peter D. Arkwright,Sara Sebnem Kilic,Jamila El Baghdadi,Shigeaki Nonoyama,Yoshiyuki Minegishi,Seyed Alireza Mahdaviani,Davood Mansouri,Aziz Bousfiha,Annaliesse Blincoe,Martyn A. French,Martyn A. French,Peter Hsu,Dianne E. Campbell,Michael Stormon,Melanie Wong,Stephen Adelstein,Joanne Smart,David A. Fulcher,Matthew C. Cook,Matthew C. Cook,Tri Giang Phan,Tri Giang Phan,Polina Stepensky,Kaan Boztug,Kaan Boztug,Aydan Kansu,Aydan Ikinciogullari,Ulrich Baumann,Rita Beier,Tony Roscioli,Tony Roscioli,John B. Ziegler,Paul Gray,Capucine Picard,Bodo Grimbacher,Klaus Warnatz,Steven M. Holland,Jean-Laurent Casanova,Gulbu Uzel,Stuart G. Tangye,Stuart G. Tangye +59 more
TL;DR: Findings shed new light on TFH cell biology and the integrated signaling pathways required for their generation, maintenance, and effector function and explain the compromised humoral immunity seen in patients with some PIDs.
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References
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation.
Robert J. Johnston,Amanda C. Poholek,Daniel DiToro,Isharat Yusuf,Danelle Eto,Burton E. Barnett,Alexander L. Dent,Joe Craft,Shane Crotty,Shane Crotty +9 more
TL;DR: It is found that expression of the transcription factor Bcl6 in CD4+ T cells is both necessary and sufficient for in vivo TFH differentiation and T cell help to B cells in mice, and that Bcl 6 and Blimp-1 play central but opposing roles inTFH differentiation.
Bcl6 Mediates the Development of T Follicular Helper Cells
Roza Nurieva,Yeonseok Chung,Gustavo J. Martinez,Xuexian O. Yang,Shinya Tanaka,Tatyana D. Matskevitch,Yi Hong Wang,Chen Dong +7 more
TL;DR: It is demonstrated that the transcription factor Bcl6 is both necessary and sufficient for TFH differentiation and subsequent B cell–mediated immunity, suggesting that it is a master regulator of this lineage.
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Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production
Dagmar Breitfeld,Lars Ohl,Elisabeth Kremmer,Joachim W. Ellwart,Federica Sallusto,Martin Lipp,Reinhold Förster +6 more
TL;DR: In this article, expression of CXC chemokine receptor 5 (CXCR5) defines a novel subpopulation of B helper T cells localizing to follicles, based on the characteristic localization within secondary lymphoid organs.
1.4K
A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R
Christi L. Parham,Madaline Chirica,Jacqueline C. Timans,Elena Vaisberg,Marilyn Travis,Jeanne Cheung,Stefan Pflanz,Rebecca Zhang,Komal Singh,Felix Vega,Wayne To,Janet Wagner,Anne Marie O'Farrell,Terrill K. McClanahan,Sandra Zurawski,Charles H. Hannum,Daniel M. Gorman,Donna Rennick,Robert A. Kastelein,Rene de Waal Malefyt,Kevin W. Moore +20 more
TL;DR: A novel member of the hemopoietin receptor family is identified as a subunit of the receptor for IL-23, “IL-23R,” which pairs with IL-12Rβ1 to confer IL- 23 responsiveness on cells expressing both subunits.
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Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function
Patrick Schaerli,Katharina Willimann,Alois B. Lang,Martin Lipp,Pius Loetscher,Bernhard Moser +5 more
TL;DR: These properties portray CXCR5+ T cells as a distinct memory T cell subset with B cell helper function, designated here as follicular B helper T cells (TFH).
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