Functional STAT3 deficiency compromises the generation of human T follicular helper cells
Cindy S. Ma,Cindy S. Ma,Danielle T. Avery,Anna Chan,Marcel Batten,Marcel Batten,Jacinta Bustamante,Jacinta Bustamante,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Peter D. Arkwright,Alexandra Y. Kreins,Diana Averbuch,Dan Engelhard,Klaus Magdorf,Sara Sebnem Kilic,Yoshiyuki Minegishi,Shigeaki Nonoyama,Martyn A. French,Martyn A. French,Sharon Choo,Joanne Smart,Jane Peake,Melanie Wong,Paul Gray,Matthew C. Cook,Matthew C. Cook,David A. Fulcher,Jean-Laurent Casanova,Jean-Laurent Casanova,Elissa K. Deenick,Elissa K. Deenick,Stuart G. Tangye,Stuart G. Tangye +33 more
311
TL;DR: CD4(+) T cells from patients deficient in IL-12Rβ1, TYK2, STAT1, and STAT3 are examined to further explore the pathways involved in human Tfh cell differentiation and suggest that defective T fh cell development and/or function contributes to the humoral defects observed in STAT3-deficient patients.
read more
About: This article is published in Blood. The article was published on 26 Apr 2012. and is currently open access. The article focuses on the topics: Interleukin 21 & Cytotoxic T cell.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
STAT3-confusion-of-function: beyond the loss and gain dualism.
Lorenzo Lodi,Laura Faletti,Maria Elena Maccari,Filippo Consonni,Miriam Gross,Ilaria Pagnini,Silvia Ricci,Maximilian Heeg,Gabriele Simonini,Chiara Azzari,Stephan Ehl +10 more
TL;DR: In this paper , a patient with Sjögren syndrome and features of AD-HIES with this mutation is described and the molecular consequences are further characterized, which is matched by an ambiguous clinical and immunological phenotype that dismantles the classical antithetic dualism of gain- versus loss-offunction.
T follicular helper cells and T follicular regulatory cells in rheumatic diseases.
TL;DR: By identifying the molecular mechanisms underlying the development and function of these cell populations, new opportunities have emerged to develop novel therapeutic targets and inspire more approaches to reinstate the balance of these cells in the prevention and treatment of rheumatic diseases.
Inborn errors of human STAT1: allelic heterogeneity governs the diversity of immunological and infectious phenotypes.
Stéphanie Boisson-Dupuis,Xiao-Fei Kong,Satoshi Okada,Sophie Cypowyj,Anne Puel,Anne Puel,Laurent Abel,Laurent Abel,Laurent Abel,Jean-Laurent Casanova +9 more
TL;DR: Germline mutations in human STAT1 define four distinct clinical disorders, various combinations of viral, mycobacterial and fungal infections are therefore allelic at the humanSTAT1 locus.
Multi-Source Pathways of T Follicular Helper Cell Differentiation.
Xiaoxue Ma,Shingo Nakayamada +1 more
TL;DR: In this paper, the authors summarized the roles of different STATs in mediating Tfh subsets, analyzed the contributions of mutual restraint and cooperation among cytokine-STAT signals to terminal TfH differentiation, and clarified the multi-source pathways of TFh differentiation with a three-dimensional illustration.
Additional file 2 of Integrated systems immunology approach identifies impaired effector T cell memory responses as a feature of progression to severe dengue fever
Liao Yang,Shi Wei +1 more
- 14 Apr 2023
Abstract: Additional file 2: TableS2: Cell surface makers included as parameters in viSNE analysis. Surface markers used for unsupervised high-dimensional analysis of major blood cell populations.
References
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation.
Robert J. Johnston,Amanda C. Poholek,Daniel DiToro,Isharat Yusuf,Danelle Eto,Burton E. Barnett,Alexander L. Dent,Joe Craft,Shane Crotty,Shane Crotty +9 more
TL;DR: It is found that expression of the transcription factor Bcl6 in CD4+ T cells is both necessary and sufficient for in vivo TFH differentiation and T cell help to B cells in mice, and that Bcl 6 and Blimp-1 play central but opposing roles inTFH differentiation.
Bcl6 Mediates the Development of T Follicular Helper Cells
Roza Nurieva,Yeonseok Chung,Gustavo J. Martinez,Xuexian O. Yang,Shinya Tanaka,Tatyana D. Matskevitch,Yi Hong Wang,Chen Dong +7 more
TL;DR: It is demonstrated that the transcription factor Bcl6 is both necessary and sufficient for TFH differentiation and subsequent B cell–mediated immunity, suggesting that it is a master regulator of this lineage.
1.5K
Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production
Dagmar Breitfeld,Lars Ohl,Elisabeth Kremmer,Joachim W. Ellwart,Federica Sallusto,Martin Lipp,Reinhold Förster +6 more
TL;DR: In this article, expression of CXC chemokine receptor 5 (CXCR5) defines a novel subpopulation of B helper T cells localizing to follicles, based on the characteristic localization within secondary lymphoid organs.
1.4K
A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R
Christi L. Parham,Madaline Chirica,Jacqueline C. Timans,Elena Vaisberg,Marilyn Travis,Jeanne Cheung,Stefan Pflanz,Rebecca Zhang,Komal Singh,Felix Vega,Wayne To,Janet Wagner,Anne Marie O'Farrell,Terrill K. McClanahan,Sandra Zurawski,Charles H. Hannum,Daniel M. Gorman,Donna Rennick,Robert A. Kastelein,Rene de Waal Malefyt,Kevin W. Moore +20 more
TL;DR: A novel member of the hemopoietin receptor family is identified as a subunit of the receptor for IL-23, “IL-23R,” which pairs with IL-12Rβ1 to confer IL- 23 responsiveness on cells expressing both subunits.
1.4K
Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function
Patrick Schaerli,Katharina Willimann,Alois B. Lang,Martin Lipp,Pius Loetscher,Bernhard Moser +5 more
TL;DR: These properties portray CXCR5+ T cells as a distinct memory T cell subset with B cell helper function, designated here as follicular B helper T cells (TFH).
1.3K