Journal Article10.1038/42408
Functional rafts in cell membranes
Kai Simons,Elina Ikonen +1 more
9.9K
TL;DR: A new aspect of cell membrane structure is presented, based on the dynamic clustering of sphingolipids and cholesterol to form rafts that move within the fluid bilayer that function as platforms for the attachment of proteins when membranes are moved around inside the cell and during signal transduction.
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Abstract: A new aspect of cell membrane structure is presented, based on the dynamic clustering of sphingolipids and cholesterol to form rafts that move within the fluid bilayer. It is proposed that these rafts function as platforms for the attachment of proteins when membranes are moved around inside the cell and during signal transduction.
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Citations
Interactions of surfactants with lipid membranes.
TL;DR: The biophysics of the interactions of surfactants with membranes of insoluble, naturally occurring lipids is reviewed, including structural, thermodynamic and kinetic aspects of membrane–water partitioning, changes in membrane properties induced by surfactant properties, and other phases formed by lipid–surfactant systems are discussed.
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Released GFRα1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts
Gustavo Paratcha,Fernanda Ledda,Louise Baars,Muriel Coulpier,Valerie Besset,Jonas Anders,Rizaldy P. Scott,Carlos F. Ibáñez +7 more
TL;DR: The results provide an explanation for the tissue distribution of GFRalpha1 and support the physiological importance of c-Ret activation in trans as a novel mechanism to potentiate and diversify the biological responses to GDNF.
312
Endocytosis of gene delivery vectors: from clathrin-dependent to lipid raft-mediated endocytosis.
TL;DR: This review covers the well-recognized clathrin-mediated endocytosis (CME), phagocytotic, and macropinocyTosis in addition to the less addressed pathways that take place in lipid rafts, and summarizes the regulators associated with each uptake pathway.
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Lessons of Slicing Membranes: Interplay of Packing, Free Area, and Lateral Diffusion in Phospholipid/Cholesterol Bilayers
TL;DR: It is found that cholesterol has a strong impact on the free area properties of the bilayer, highlighting the central role of free area in comprehending the structural and dynamic properties of membranes containing cholesterol.
310
Protein Crowding in Lipid Bilayers Gives Rise to Non-Gaussian Anomalous Lateral Diffusion of Phospholipids and Proteins
Jae-Hyung Jeon,Jae-Hyung Jeon,Matti Javanainen,Matti Javanainen,Hector Martinez-Seara,Hector Martinez-Seara,Ralf Metzler,Ralf Metzler,Ilpo Vattulainen,Ilpo Vattulainen,Ilpo Vattulainen +10 more
TL;DR: In this paper, an investigation into how lipids diffuse in the presence of varying protein:lipid number ratios reveals that protein crowding results in drastically different lipid and protein diffusion due to the strengthened impact of correlated motion.
310
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S. J. Singer,Garth L. Nicolson +1 more
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TL;DR: Results strongly indicate that the bivalent antibodies produce an aggregation of the surface immunoglobulin molecules in the plane of the membrane, which can occur only if the immunoglOBulin molecules are free to diffuse in the membrane.
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TL;DR: It is shown that caveolin interacts with another well characterized signal transducer, Ras, and that recombinant overexpression of caveolin in intact cells is sufficient to functionally recruit a nonfarnesylated mutant of Ras onto membranes, overcoming the normal requirement for lipid modification of Ras.
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