Functional rafts in cell membranes

TL;DR: A combination of multiple precursor ion scans allowed quantitative monitoring of major perturbation in phospholipid composition and elucidating of molecular heterogeneity of individual lipid species.

TL;DR: With the exception of pancreatic cancer, high rates of CD24 are significantly associated with a more aggressive course of the disease, a finding that remains significant in a multivariate analysis.

TL;DR: It is concluded that lipid-lipid interactions alone can originate lipid rafts on very different length scales and the conclusions presented here are consistent with the literature concerning both model systems and cell membrane studies.

TL;DR: The synthesis, regulation, and intracellular distribution of SMs are discussed, and the many direct roles played by membrane SM in various cellular functions and processes will also be discussed.

TL;DR: It is shown that a protein with a glycosylphosphatidyl inositol (GPI) anchor can be recovered from lysates of epithelial cells in a low density, detergent-insoluble form, supporting the model proposed by Simons and colleagues for sorting of certain membrane proteins to the apical surface after intracellular association with glycosphingolipids.

TL;DR: Results strongly indicate that the bivalent antibodies produce an aggregation of the surface immunoglobulin molecules in the plane of the membrane, which can occur only if the immunoglOBulin molecules are free to diffuse in the membrane.

TL;DR: Polarized epithelial cells play fundamental roles in the ontogeny and function of a variety of tissues and organs in mammals and are the first overt sign of cellular differentiation in early embryonic development.

TL;DR: It is shown that caveolin interacts with another well characterized signal transducer, Ras, and that recombinant overexpression of caveolin in intact cells is sufficient to functionally recruit a nonfarnesylated mutant of Ras onto membranes, overcoming the normal requirement for lipid modification of Ras.