Functional rafts in cell membranes

TL;DR: It is found that TMDs are not generic but have organelle-specific properties with a dichotomy in TMD length between the early and late parts of the secretory pathway.

TL;DR: The present picture of cell membranes as lipid bilayers is the legacy of a century's study that concentrated on the lipids and proteins of cell-surface membranes.

TL;DR: A simulation model is applied to assess the molecular nature of domains formed in ternary mixtures, showing the spontaneous separation of a saturated phosphatidylcholine (PC)/unsaturated PC/cholesterol mixture into a liquid-ordered and aLiquid-disordered phase with structural and dynamic properties closely matching experimental data.

TL;DR: Having a better understanding of the role of macrophages in the tissue healing processes, especially in events that follow biomaterial implantation, can design novel biomaterials-based tissue-engineered constructs that elicit a favorable immune response upon implantation and perform for their intended applications.

TL;DR: It is shown that a protein with a glycosylphosphatidyl inositol (GPI) anchor can be recovered from lysates of epithelial cells in a low density, detergent-insoluble form, supporting the model proposed by Simons and colleagues for sorting of certain membrane proteins to the apical surface after intracellular association with glycosphingolipids.

TL;DR: Results strongly indicate that the bivalent antibodies produce an aggregation of the surface immunoglobulin molecules in the plane of the membrane, which can occur only if the immunoglOBulin molecules are free to diffuse in the membrane.

TL;DR: Polarized epithelial cells play fundamental roles in the ontogeny and function of a variety of tissues and organs in mammals and are the first overt sign of cellular differentiation in early embryonic development.

TL;DR: It is shown that caveolin interacts with another well characterized signal transducer, Ras, and that recombinant overexpression of caveolin in intact cells is sufficient to functionally recruit a nonfarnesylated mutant of Ras onto membranes, overcoming the normal requirement for lipid modification of Ras.