Journal Article10.1126/sciadv.adj4047
Functional metal-phenolic cortical cytoskeleton for artificial cells
Zhen-Hong Luo,Chen Chen,Qi-Hong Zhao,Nan-Nan Deng +3 more
8
TL;DR: Functional metal-phenolic cortical cytoskeleton for artificial cells TLDR: Metal-phenolic networks serve as a functional cortical cytoskeleton in liposome-based artificial cells, exhibiting long-term stability, enhanced resistance to harsh environments, tunable permeability, and controlled morphologies.
read more
Abstract: Cortex-like cytoskeleton, a thin layer of cross-linked cytoplasmic proteins underlying the cell membrane, plays an essential role in modulating membrane behavior and cell surface properties. However, bottom-up construction of functional cortex-like cytoskeleton in artificial cells remains a challenge. Here, we present metal-phenolic networks as artificial cortical cytoskeletons in liposome-based artificial cells. The metal-phenolic cytoskeleton–reinforced artificial cells exhibit long-term stability, enhanced resistance to a variety of harsh environments, tunable permeability, and well-controlled morphologies. We anticipate that our stable artificial cell models will stride forward to practical applications of liposome-based microsystem.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Cell Membrane Engineered Polypeptide Nanonets Mimicking Macrophage Aggregates for Enhanced Antibacterial Treatment
Jiang Xiao,Zhili Song,Tengfei Liu,Zengchao Guo,Xiaohui Liu,Hui Jiang,Xuemei Wang +6 more
TL;DR: This study proposes a multifunctional and enhanced antibacterial strategy through the construction of novel biomimetic cell membrane polypeptide nanonets (R-DPB-TA-Ce), showcasing the exceptional treatment effect of R-DPB-TA-Ce as a new biomimetic assembled drug delivery system in antibacterial, anti-inflammatory, and wound healing promotion.
1
Precision Self‐Assembly of Supramolecules with Heterogeneous Derivatives
Jiawen Zhang,Li Xiang,Binglin Zhou,Yuhao Zhang,Weijie Zhang,Jinyang Jiang,Hongbo Zeng +6 more
TL;DR: Researchers develop a programmable self-assembly strategy for supramolecules with heterogeneous derivatives, achieving reversible assembly, reduced precipitation, and durability, and propose a general criterion for high precision self-assembly applicable to complex interactions and derivatives.
1
Surface-Initiated Synergistic Disassembly of Metal-Phenolic Networks by Redox and Hydrolytic Reactions
Wenting Liao,Bohan Cheng,Chenyu Wang,Joseph J. Richardson,Mitsuru Naito,Kanjiro Miyata,Hirotaka Ejima +6 more
1
Electrical Microneedles for Wound Treatment
Yu Wang,Lijun Cai,Fan Lü,Wang Li,Feika Bian,Weijian Sun,Yuanjin Zhao +6 more
TL;DR: This review summarizes state-of-art research on electrical microneedles for wound treatment, highlighting their unique features, mechanisms, and applications in accelerating wound healing, and discusses future directions for their development and improvement.
1
Research progress of probiotics and their protective strategy in the field of inflammatory bowel disease treatment: A review
TL;DR: This review explores the use of probiotics in treating inflammatory bowel disease (IBD), highlighting their ability to regulate intestinal microbiota, inhibit pathogenic bacteria, and promote mucosal repair, while also discussing challenges and future trends in probiotic development and delivery.
1
References
Cell-sized asymmetric lipid vesicles facilitate the investigation of asymmetric membranes
TL;DR: The formation of asymmetric giant vesicles that include little organic solvent are described, and used to investigate the dynamic responses of lipid molecules in the vesicle membrane to reveal that the lipid asymmetry in bilayer membranes improves the reconstitution ratio of membrane proteins.
Nonenzymatic biomimetic remodeling of phospholipids in synthetic liposomes
TL;DR: In this article, reversible chemoselective reactions can be harnessed to achieve nonenzymatic spontaneous remodeling of phospholipids in synthetic membranes, relying on transthioesterification/acyl shift reactions that occur spontaneously and reversibly between tertiary amides and thioesters.
An Adaptive Synthetic Cell Based on Mechanosensing, Biosensing, and Inducible Gene Circuits.
TL;DR: This work constructs a synthetic cell equipped with an inducible genetic circuit that responds to changes in osmotic pressure through the mechanosensitive channel MscL, the first example of molecular integration that couples mechanosensitivity, gene expression, and self-assembly at the inner membrane of synthetic cells.