Journal Article10.1016/J.LFS.2020.118377
Functional implications of vascular endothelium in regulation of endothelial nitric oxide synthesis to control blood pressure and cardiac functions
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TL;DR: The central role of vascular endothelium in the regulation of endothelial nitric oxide synthase is described while outlining the emerging drug targets present in the vasculature with potential to treat vascular disorders including hypertension.
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About: This article is published in Life Sciences. The article was published on 15 Oct 2020. The article focuses on the topics: Endothelium & Nitric oxide.
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Citations
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Acylation targets endothelial nitric oxide synthase to plasmalemmal caveolae
Philip W. Shaul,Eric J. Smart,Eric J. Smart,Lisa J. Robinson,Lisa J. Robinson,Zohre German,Zohre German,Ivan S. Yuhanna,Ivan S. Yuhanna,Yun-shu Ying,Yun-shu Ying,Richard G.W. Anderson,Richard G.W. Anderson,Thomas Michel,Thomas Michel +14 more
TL;DR: In this paper, the authors used immunoblot analysis to determine whether eNOS is localized to plasmalemmal microdomains implicated in signal transduction called caveolae.
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Recent Advances in Phthalocyanine and Porphyrin-Based Materials as Active Layers for Nitric Oxide Chemical Sensors
TL;DR: In this paper , the state of research over the past ten years in the field of applications of phthalocyanines, porphyrins and their hybrid materials as active layers of chemical sensors for the detection of NO, with a primary focus on chemiresistive and electrochemical ones.
•Journal Article
Direct interaction of endothelial nitric oxide synthase and caveolin-1 inhibits synthase activity
TL;DR: In this paper, the authors have cloned the bovine caveolin-1 cDNA and have investigated the eNOS-caveolin 1 interaction in an in vitrobinding assay system using glutathione S-transferase (GST)-caveol-1 fusion proteins.
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Epigallocatechin gallate (EGCG) alleviates vascular dysfunction in angiotensin II-infused hypertensive mice by modulating oxidative stress and eNOS
TL;DR: The role of epigallocatechin gallate (EGCG) in improving vascular function via modulation of endothelial nitric oxide synthase (eNOS) in hypertensive subjects is not well researched as mentioned in this paper .
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TL;DR: Dopamine β hydroxylase, a key player in the catecholamine biosynthetic pathway, may provide a therapeutic opportunity and should be extensively explored as a target for potent anti-hypertensives.
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TL;DR: The potential role of the endothelium in venous thrombosis with and without overt vessel wall injury is discussed and the vast majority of endothelial cells are located in the microvessels.
Compartmentalized Connexin 43 S-Nitrosylation/Denitrosylation Regulates Heterocellular Communication in the Vessel Wall
Adam C. Straub,Marie Billaud,Scott R. Johnstone,Angela K. Best,Sean Yemen,Scott Dwyer,Robin Looft-Wilson,Jeffery J. Lysiak,Benjamin Gaston,Lisa A. Palmer,Brant E. Isakson +10 more
TL;DR: Evidence is provided for compartmentalized S-nitrosoglutathione reductase activity to precede NO release in the regulation of smooth muscle cell to endothelial cell communication.