Journal Article10.1016/J.LFS.2020.118377
Functional implications of vascular endothelium in regulation of endothelial nitric oxide synthesis to control blood pressure and cardiac functions
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TL;DR: The central role of vascular endothelium in the regulation of endothelial nitric oxide synthase is described while outlining the emerging drug targets present in the vasculature with potential to treat vascular disorders including hypertension.
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About: This article is published in Life Sciences. The article was published on 15 Oct 2020. The article focuses on the topics: Endothelium & Nitric oxide.
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Citations
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Acylation targets endothelial nitric oxide synthase to plasmalemmal caveolae
Philip W. Shaul,Eric J. Smart,Eric J. Smart,Lisa J. Robinson,Lisa J. Robinson,Zohre German,Zohre German,Ivan S. Yuhanna,Ivan S. Yuhanna,Yun-shu Ying,Yun-shu Ying,Richard G.W. Anderson,Richard G.W. Anderson,Thomas Michel,Thomas Michel +14 more
TL;DR: In this paper, the authors used immunoblot analysis to determine whether eNOS is localized to plasmalemmal microdomains implicated in signal transduction called caveolae.
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Fetoplacental vasculature as a model to study human cardiovascular endocrine disruption.
Margarida Lorigo,Elisa Cairrao +1 more
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Recent Advances in Phthalocyanine and Porphyrin-Based Materials as Active Layers for Nitric Oxide Chemical Sensors
TL;DR: In this paper , the state of research over the past ten years in the field of applications of phthalocyanines, porphyrins and their hybrid materials as active layers of chemical sensors for the detection of NO, with a primary focus on chemiresistive and electrochemical ones.
•Journal Article
Direct interaction of endothelial nitric oxide synthase and caveolin-1 inhibits synthase activity
TL;DR: In this paper, the authors have cloned the bovine caveolin-1 cDNA and have investigated the eNOS-caveolin 1 interaction in an in vitrobinding assay system using glutathione S-transferase (GST)-caveol-1 fusion proteins.
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Epigallocatechin gallate (EGCG) alleviates vascular dysfunction in angiotensin II-infused hypertensive mice by modulating oxidative stress and eNOS
TL;DR: The role of epigallocatechin gallate (EGCG) in improving vascular function via modulation of endothelial nitric oxide synthase (eNOS) in hypertensive subjects is not well researched as mentioned in this paper .
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Endothelium-derived hyperpolarizing factor and vascular function
Muhiddin Ozkor,Arshed A. Quyyumi +1 more
TL;DR: The mechanisms underlying endothelial dysfunction need to be fully understood, so that adequate therapeutic interventions can be designed, and a compensatory up-regulation of hyperpolarization in states characterized by reduced NO availability is suggested.
Mineralocorticoid Receptor Blockade Improves Vasomotor Dysfunction and Vascular Oxidative Stress Early After Myocardial Infarction
Carmem Luíza Sartório,Daniela Fraccarollo,Paolo Galuppo,Meike Leutke,Georg Ertl,Ivanita Stefanon,Johann Bauersachs +6 more
TL;DR: Underlying mechanisms involve inhibition of vascular angiotensin-converting enzyme upregulation and improvement of endothelial NO synthase–derived NO bioavailability and improved endothelial dysfunction in the early phase post-MI.
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Histone Deacetylase 3 Antagonizes Aspirin-Stimulated Endothelial Nitric Oxide Production by Reversing Aspirin-Induced Lysine Acetylation of Endothelial Nitric Oxide Synthase
Saet-Byel Jung,Cuk-Seong Kim,Asma Naqvi,Tohru Yamamori,Ilwola Mattagajasingh,Timothy A. Hoffman,Marsha P. Cole,Ajay Kumar,Jeremy DeRicco,Byeong Hwa Jeon,Kaikobad Irani +10 more
TL;DR: Lysine acetylation of eNOS is a posttranslational protein modification supporting low-dose aspirin-induced vasoprotection and antagonizes aspirin-stimulated endothelial production of NO in a cyclooxygenase-1–independent fashion.
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Human cytochrome b5 reductase: structure, function, and potential applications
TL;DR: A comprehensive overview of the structure and function of cytochrome b5 reductase from different eukaryotic sources and its potential use in the food industry, biosensor, and diagnostic areas is provided.
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Post-translational mechanisms of endothelial nitric oxide synthase regulation by bradykinin.
TL;DR: This brief review summarizes the current state of knowledge with regard to regulation of eNOS through several distinct molecular mechanisms, each of which acts in concert with Ca2+-calmodulin (CaM) signaling in post-translational activation ofeNOS.
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