Journal Article10.2174/187569208786733857
Functional Crosstalk Between β2-adrenoreceptor and Muscarinic Acetylcholine Receptor: Implications for Gene-Gene Interactions and Bronchodilatory Responses in Patients with Asthma and COPD
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About: This article is published in Current Pharmacogenomics and Personalized Medicine. The article was published on 30 Nov 2008. The article focuses on the topics: Muscarinic acetylcholine receptor & Crosstalk (biology).
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Citations
Preclinical efficacy of THRX-200495, a dual pharmacology muscarinic receptor antagonist and β(2)-adrenoceptor agonist (MABA).
Alexander McNamara,Tod Steinfeld,MT Pulido-Rios,Eric L. Stangeland,Sharath S. Hegde,Mathai Mammen,William J. Martin +6 more
TL;DR: A dual-acting prototypical MABA, THRX-200495, demonstrated potent, balanced and long-lasting bronchodilation in a guinea pig model of bronchoprotection that was greater than either the MA or BA mechanisms alone.
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Tilman E. Klassert,Shyam A. Patel,Pranela Rameshwar +2 more
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TL;DR: This review discusses the existence of a complex network involving the neurokinin receptors, tachykinins and cytokines and shows that neural control of this process is emerging as a significant category in hematopoietic modulation.
The impact of genomic variants on patient response to inhaled bronchodilators: a comprehensive update
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