Journal Article10.1002/MRM.1910340409
Functional connectivity in the motor cortex of resting human brain using echo-planar MRI.
9.7K
TL;DR: It is concluded that correlation of low frequency fluctuations, which may arise from fluctuations in blood oxygenation or flow, is a manifestation of functional connectivity of the brain.
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Abstract: An MRI time course of 512 echo-planar images (EPI) in resting human brain obtained every 250 ms reveals fluctuations in signal intensity in each pixel that have a physiologic origin. Regions of the sensorimotor cortex that were activated secondary to hand movement were identified using functional MRI methodology (FMRI). Time courses of low frequency (< 0.1 Hz) fluctuations in resting brain were observed to have a high degree of temporal correlation (P < 10(-3)) within these regions and also with time courses in several other regions that can be associated with motor function. It is concluded that correlation of low frequency fluctuations, which may arise from fluctuations in blood oxygenation or flow, is a manifestation of functional connectivity of the brain.
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References
Epigenetic transmission of the impact of early stress across generations.
Tamara B. Franklin,Holger Russig,Holger Russig,Isabelle C Weiss,Isabelle C Weiss,Johannes Gräff,Natacha Linder,Natacha Linder,Aubin Michalon,Sándor Vizi,Sándor Vizi,Isabelle M. Mansuy,Isabelle M. Mansuy +12 more
TL;DR: It is shown that chronic and unpredictable maternal separation induces depressive-like behaviors and alters the behavioral response to aversive environments in the separated animals when adult, highlighting the negative impact of early stress on behavioral responses across generations and on the regulation of DNA methylation in the germline.
1.1K
The underpinnings of the BOLD functional magnetic resonance imaging signal.
TL;DR: The good coverage and high resolution afforded by functional magnetic resonance imaging make it an excellent tool for the noninvasive imaging of the human brain and the use of this technique in animal studies using high magnetic fields is interesting.
1.1K
Children with autism fail to orient to naturally occurring social stimuli.
TL;DR: It was found that, compared to children with Down syndrome or typical development, children with autism more frequently failed to orient to all stimuli, and that this failure was much more extreme for social stimuli.
Chemical constituents of marijuana: The complex mixture of natural cannabinoids
Mahmoud A. ElSohly,Desmond Slade +1 more
TL;DR: The chemical constituents of the plant are discussed with particular emphasis on the cannabinoids as the class of compounds responsible for the drug's psychological properties.
1K
Compassionate Mind Training for People with High Shame and Self-Criticism: Overview and Pilot Study of a Group
Therapy Approach,Paul Gilbert,Sue Procter +2 more
- 01 Jan 2006
TL;DR: In this article, a short overview of the role of shame and self-criticism in psychological difficulties, the importance of considering different types of affect system (activating versus soothing) and the theory and therapy process of Compassionate Mind Training (CMT) is presented.
1K