Journal Article10.1002/MRM.1910340409
Functional connectivity in the motor cortex of resting human brain using echo-planar MRI.
9.7K
TL;DR: It is concluded that correlation of low frequency fluctuations, which may arise from fluctuations in blood oxygenation or flow, is a manifestation of functional connectivity of the brain.
read more
Abstract: An MRI time course of 512 echo-planar images (EPI) in resting human brain obtained every 250 ms reveals fluctuations in signal intensity in each pixel that have a physiologic origin. Regions of the sensorimotor cortex that were activated secondary to hand movement were identified using functional MRI methodology (FMRI). Time courses of low frequency (< 0.1 Hz) fluctuations in resting brain were observed to have a high degree of temporal correlation (P < 10(-3)) within these regions and also with time courses in several other regions that can be associated with motor function. It is concluded that correlation of low frequency fluctuations, which may arise from fluctuations in blood oxygenation or flow, is a manifestation of functional connectivity of the brain.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Advances in functional and structural MR image analysis and implementation as FSL.
Stephen M. Smith,Mark Jenkinson,Mark W. Woolrich,Mark W. Woolrich,Christian F. Beckmann,Behrens Tej.,Heidi Johansen-Berg,Peter R. Bannister,M De Luca,Ivana Drobnjak,D E Flitney,Rami K. Niazy,J Saunders,J Vickers,Yongyue Zhang,N. De Stefano,J M Brady,Paul M. Matthews +17 more
TL;DR: A review of the research carried out by the Analysis Group at the Oxford Centre for Functional MRI of the Brain (FMRIB) on the development of new methodologies for the analysis of both structural and functional magnetic resonance imaging data.
14K
The Brain's Default Network Anatomy, Function, and Relevance to Disease
TL;DR: Past observations are synthesized to provide strong evidence that the default network is a specific, anatomically defined brain system preferentially active when individuals are not focused on the external environment, and for understanding mental disorders including autism, schizophrenia, and Alzheimer's disease.
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Michael D. Fox,Abraham Z. Snyder,Justin L. Vincent,Maurizio Corbetta,David C. Van Essen,Marcus E. Raichle +5 more
TL;DR: It is suggested that both task-driven neuronal responses and behavior are reflections of this dynamic, ongoing, functional organization of the brain, featuring the presence of anticorrelated networks in the absence of overt task performance.
9.1K
The organization of the human cerebral cortex estimated by intrinsic functional connectivity
B.T. Thomas Yeo,Fenna M. Krienen,Jorge Sepulcre,Jorge Sepulcre,Mert R. Sabuncu,Mert R. Sabuncu,Danial Lashkari,Marisa O. Hollinshead,Marisa O. Hollinshead,Joshua L. Roffman,Jordan W. Smoller,Lilla Zöllei,Jonathan R. Polimeni,Bruce Fischl,Bruce Fischl,Hesheng Liu,Randy L. Buckner +16 more
TL;DR: In this paper, the organization of networks in the human cerebrum was explored using resting-state functional connectivity MRI data from 1,000 subjects and a clustering approach was employed to identify and replicate networks of functionally coupled regions across the cerebral cortex.
7.4K
Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive Control
William W. Seeley,Vinod Menon,Alan F. Schatzberg,Jennifer Keller,Gary H. Glover,Heather A. Kenna,Allan L. Reiss,Michael D. Greicius +7 more
TL;DR: Two distinct networks typically coactivated during functional MRI tasks are identified, anchored by dorsal anterior cingulate and orbital frontoinsular cortices with robust connectivity to subcortical and limbic structures, and an “executive-control network” that links dorsolateral frontal and parietal neocortices.
7.2K
References
Nonpharmacological Interventions for ADHD: Systematic Review and Meta-Analyses of Randomized Controlled Trials of Dietary and Psychological Treatments
Edmund J.S. Sonuga-Barke,Daniel Brandeis,Samuele Cortese,David Daley,Maite Ferrin,Martin Holtmann,Jim Stevenson,Marina Danckaerts,Saskia Van der Oord,Manfred Döpfner,Ralf W. Dittmann,Emily Simonoff,Alessandro Zuddas,Tobias Banaschewski,Jan Buitelaar,David Coghill,Chris Hollis,Eric Konofal,Michel Lecendreux,Ian C. K. Wong,Joseph Sergeant +20 more
TL;DR: Better evidence for efficacy from blinded assessments is required for behavioral interventions, neurofeedback, cognitive training, and restricted elimination diets before they can be supported as treatments for core ADHD symptoms.
1.1K
Towards a Knowledge‐based Theory of the Geographical Cluster
TL;DR: The very reasons why cognitive distance might be small within the cluster tend to make cognitive distance great between clusters and make interfirm co-operation across bodies of knowledge more costly as discussed by the authors.
1.1K
Analysis of the bread wheat genome using whole-genome shotgun sequencing
Rachel Brenchley,Manuel Spannagl,Matthias Pfeifer,Gary L A Barker,Rosalinda D’Amore,Alexandra M. Allen,Neil McKenzie,Melissa Kramer,Arnaud Kerhornou,Dan Bolser,Suzanne Kay,Darren Waite,Martin Trick,Ian Bancroft,Y. Q. Gu,Naxin Huo,Ming-Cheng Luo,Sunish K. Sehgal,Bikram S. Gill,S. F. Kianian,Olin D. Anderson,Paul J. Kersey,Jan Dvorak,W. Richard McCombie,Anthony Hall,Klaus F. X. Mayer,Keith J. Edwards,Michael W. Bevan,Neil Hall +28 more
TL;DR: It is shown that the hexaploid genome is highly dynamic, with significant loss of gene family members on polyploidization and domestication, and an abundance of gene fragments.
The utility of simulation in medical education: what is the evidence?
Yasuharu Okuda,Ethan O. Bryson,Samuel DeMaria,Lisa Jacobson,Joshua Quinones,Bing Shen,Adam I. Levine +6 more
TL;DR: Multiple studies have demonstrated the effectiveness of simulation in the teaching of basic science and clinical knowledge, procedural skills, teamwork, and communication as well as assessment at the undergraduate and graduate medical education levels.
1.1K
Dissociable Deficits in the Decision-Making Cognition of Chronic Amphetamine Abusers, Opiate Abusers, Patients with Focal Damage to Prefrontal Cortex, and Tryptophan-Depleted Normal Volunteers: Evidence for Monoaminergic Mechanisms
Robert D. Rogers,Barry J. Everitt,Alex Baldacchino,Alison J. Blackshaw,Rachel Swainson,Katie Wynne,N B Baker,J.E. Hunter,T. Carthy,E Booker,M. London,John Francis William Deakin,Barbara J. Sahakian,Trevor W. Robbins +13 more
TL;DR: It is suggested that chronic amphetamine abusers show similar decision-making deficits to those seen after focal damage to orbitofrontal PFC, which may reflect altered neuromodulation of the orbitof prefrontal PFC and interconnected limbic-striatal systems by both the ascending 5-HT and mesocortical dopamine projections.
1.1K