Journal Article10.1038/354161A0
FtsZ ring structure associated with division in Escherichia coli.
Erfei Bi,Joe Lutkenhaus +1 more
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TL;DR: The results suggest that FtsZ self-assembles into a ring structure at the future division site and may function as a cytoskeletal element and the formation of this ring may be the point at which division is regulated.
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Abstract: Genes for cell division have been identified in Escherichia coli by the isolation of conditional lethal mutations that block cell division, but do not affect DNA replication or segregation. Of these genes, ftsZ is of great interest as it acts earliest in the division pathway, is essential, its level dictates the frequency of division, and it is thought to be the target of two cell-division inhibitors, SulA, produced in response to DNA damage, and MinCD, which prevents division at old sites. Here we have used immunoelectronmicroscopy to localize the FtsZ protein to the division site. The results suggest that FtsZ self-assembles into a ring structure at the future division site and may function as a cytoskeletal element. The formation of this ring may be the point at which division is regulated.
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Citations
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Overproduction of individual gas vesicle proteins perturbs flotation, antibiotic production and cell division in the enterobacterium Serratia sp. ATCC 39006
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Absence of the Min System Does Not Cause Major Cell Division Defects in Agrobacterium tumefaciens.
TL;DR: The data suggest that the Min system contributes to the proper regulation of FtsZ placement and subsequent cell division, and the failure to precisely place FTSZ rings at mid-cell in the min mutants impacts other cell cycle features including chromosome segregation.
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TL;DR: In this chapter, physical mechanisms of bacterial organization in space and time are presented and the focus is on mechanisms that do not rely on external cues.
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References
An inducible DNA replication-cell division coupling mechanism in E. coli
Olivier Huisman,Richard D'Ari +1 more
TL;DR: The work reported here establishes the existence of the latter type of replication-division coupling in E. coli, and shows that the sfiA gene product is an inducible component of this division inhibition mechanism which is synthesized at high levels after perturbations of DNA replication.
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Overproduction of FtsZ induces minicell formation in E. coli
John E. Ward,Joe Lutkenhaus +1 more
TL;DR: The ftsZ gene in E. coli K-12 is an essential cell division gene and a two to sevenfold increase in the level of the FtsZ protein resulted in induction of the minicell phenotype, indicating that increasing FTSZ resulted in additional division events per cell cycle.
363
Protein localization in E. coli: Is there a common step in the secretion of periplasmic and outer-membrane proteins?
TL;DR: The results suggest that most of the periplasmic and outer-membrane proteins share a common step in localization before the polypeptide becomes accessible to the processing enzyme.
363
Actin in Dividing Cells: Contractile Ring Filaments Bind Heavy Meromyosin
TL;DR: The actomyosin- like properties of the contractile ring as a mechanochemical organelle that causes cell cleavage; the probable universal occurrence of actin-like protein in all dividing animal cells; and thecontractile ring's combined sensitivity to cytochalasin B and its affinity for heavy meromyosIn, a combination unique among microfilamentous organelles.
337
ftsZ is an essential cell division gene in Escherichia coli.
Kang Dai,Joe Lutkenhaus +1 more
TL;DR: This strain was temperature sensitive for cell division and viability, confirming that ftsZ is an essential cell division gene in Escherichia coli and revealed that after a shift to the nonpermissive temperature, cell division ceased when the level of FtsZ started to decrease, indicating that septation is very sensitive to thelevel of FTSZ.
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